SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING

The reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thio...

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Autores principales:	SHAMSUZZAMAN, SHAHEEN KHAN,MOHD, ALAM,MAHBOOB
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	thiosemicarbazide pyrazolines cholest-5-en-7-one thiocarbamoyl anti-bacterial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400010
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spelling	oai:scielo:S0717-970720090004000102010-04-15SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RINGSHAMSUZZAMAN,SHAHEEN KHAN,MOHDALAM,MAHBOOB thiosemicarbazide pyrazolines cholest-5-en-7-one thiocarbamoyl anti-bacterial activity The reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thiocarbamoyl-3β-chloro cholest [5,7-cd] pyrazoline (6), respectively. The structures of the newly synthesized compounds have been established on the basis of physical, analytical and spectral data. Their antibacterial activities were tested in vitro by disk diffusion assay against Gram-positive and Gram-negative bacterial strains of bacteria.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400010en10.4067/S0717-97072009000400010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	thiosemicarbazide pyrazolines cholest-5-en-7-one thiocarbamoyl anti-bacterial activity
spellingShingle	thiosemicarbazide pyrazolines cholest-5-en-7-one thiocarbamoyl anti-bacterial activity SHAMSUZZAMAN, SHAHEEN KHAN,MOHD ALAM,MAHBOOB SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
description	The reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thiocarbamoyl-3β-chloro cholest [5,7-cd] pyrazoline (6), respectively. The structures of the newly synthesized compounds have been established on the basis of physical, analytical and spectral data. Their antibacterial activities were tested in vitro by disk diffusion assay against Gram-positive and Gram-negative bacterial strains of bacteria.
author	SHAMSUZZAMAN, SHAHEEN KHAN,MOHD ALAM,MAHBOOB
author_facet	SHAMSUZZAMAN, SHAHEEN KHAN,MOHD ALAM,MAHBOOB
author_sort	SHAMSUZZAMAN,
title	SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
title_short	SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
title_full	SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
title_fullStr	SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
title_full_unstemmed	SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
title_sort	synthesis, characterization and anti-microbial activity of new steroidal cholest-5-en-7-one derivatives fused with substituted pyrazoline ring
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400010
work_keys_str_mv	AT shamsuzzaman synthesischaracterizationandantimicrobialactivityofnewsteroidalcholest5en7onederivativesfusedwithsubstitutedpyrazolinering AT shaheenkhanmohd synthesischaracterizationandantimicrobialactivityofnewsteroidalcholest5en7onederivativesfusedwithsubstitutedpyrazolinering AT alammahboob synthesischaracterizationandantimicrobialactivityofnewsteroidalcholest5en7onederivativesfusedwithsubstitutedpyrazolinering
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SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING

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