THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT

Stimuli-responsive polymer materials have potential uses in drug delivery, tissue engineering, bioreactors, and cell-surface adhesion control. Temperature-responsive surfaces of triblock copolymers of poly(N-isopropylacrylamide)-b-polycaprolactone-b-poly(N-isopropylacrylamide) (P(NIPAAm)-b-PCL-b-P(N...

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Autores principales:	LI,LIANG, YANG,XIAOMING, LIU,FANGJUN, SHANG,JINGQI, YAN,GUOPING, LI,WEN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	block copolymers ATRP stimuli-sensitive polymers cell detachment
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400016
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id	oai:scielo:S0717-97072009000400016
record_format	dspace
spelling	oai:scielo:S0717-970720090004000162010-04-15THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENTLI,LIANGYANG,XIAOMINGLIU,FANGJUNSHANG,JINGQIYAN,GUOPINGLI,WEN block copolymers ATRP stimuli-sensitive polymers cell detachment Stimuli-responsive polymer materials have potential uses in drug delivery, tissue engineering, bioreactors, and cell-surface adhesion control. Temperature-responsive surfaces of triblock copolymers of poly(N-isopropylacrylamide)-b-polycaprolactone-b-poly(N-isopropylacrylamide) (P(NIPAAm)-b-PCL-b-P(NIPAAm)) were fabricated via atom transfer radical polymerization (ATRP). At 37 °C [above the lower critical solution temperature (LCST) of NIPAAm of 32 °C], the seeded cells adhered on the surface of the triblock copolymer, while below the LCST the cells detached from the surface spontaneously. P(NIPAAm) acted as the thermoresponsive segments of the triblock copolymer for control of cell adhesion and detachment. The thermosensitive copolymers are potentially useful as stimuli-responsive adhesion modifers for cells in biomedical felds.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400016en10.4067/S0717-97072009000400016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	block copolymers ATRP stimuli-sensitive polymers cell detachment
spellingShingle	block copolymers ATRP stimuli-sensitive polymers cell detachment LI,LIANG YANG,XIAOMING LIU,FANGJUN SHANG,JINGQI YAN,GUOPING LI,WEN THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT
description	Stimuli-responsive polymer materials have potential uses in drug delivery, tissue engineering, bioreactors, and cell-surface adhesion control. Temperature-responsive surfaces of triblock copolymers of poly(N-isopropylacrylamide)-b-polycaprolactone-b-poly(N-isopropylacrylamide) (P(NIPAAm)-b-PCL-b-P(NIPAAm)) were fabricated via atom transfer radical polymerization (ATRP). At 37 °C [above the lower critical solution temperature (LCST) of NIPAAm of 32 °C], the seeded cells adhered on the surface of the triblock copolymer, while below the LCST the cells detached from the surface spontaneously. P(NIPAAm) acted as the thermoresponsive segments of the triblock copolymer for control of cell adhesion and detachment. The thermosensitive copolymers are potentially useful as stimuli-responsive adhesion modifers for cells in biomedical felds.
author	LI,LIANG YANG,XIAOMING LIU,FANGJUN SHANG,JINGQI YAN,GUOPING LI,WEN
author_facet	LI,LIANG YANG,XIAOMING LIU,FANGJUN SHANG,JINGQI YAN,GUOPING LI,WEN
author_sort	LI,LIANG
title	THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT
title_short	THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT
title_full	THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT
title_fullStr	THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT
title_full_unstemmed	THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT
title_sort	thermosensitive poly(n-isopropylacrylamide)-b-polycaprolactone-b-poly(n-isopropylacrylamide) triblock copolymers prepared via atom transfer radical polymerization for control of cell adhesion and detachment
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400016
work_keys_str_mv	AT liliang thermosensitivepolynisopropylacrylamidebpolycaprolactonebpolynisopropylacrylamidetriblockcopolymerspreparedviaatomtransferradicalpolymerizationforcontrolofcelladhesionanddetachment AT yangxiaoming thermosensitivepolynisopropylacrylamidebpolycaprolactonebpolynisopropylacrylamidetriblockcopolymerspreparedviaatomtransferradicalpolymerizationforcontrolofcelladhesionanddetachment AT liufangjun thermosensitivepolynisopropylacrylamidebpolycaprolactonebpolynisopropylacrylamidetriblockcopolymerspreparedviaatomtransferradicalpolymerizationforcontrolofcelladhesionanddetachment AT shangjingqi thermosensitivepolynisopropylacrylamidebpolycaprolactonebpolynisopropylacrylamidetriblockcopolymerspreparedviaatomtransferradicalpolymerizationforcontrolofcelladhesionanddetachment AT yanguoping thermosensitivepolynisopropylacrylamidebpolycaprolactonebpolynisopropylacrylamidetriblockcopolymerspreparedviaatomtransferradicalpolymerizationforcontrolofcelladhesionanddetachment AT liwen thermosensitivepolynisopropylacrylamidebpolycaprolactonebpolynisopropylacrylamidetriblockcopolymerspreparedviaatomtransferradicalpolymerizationforcontrolofcelladhesionanddetachment
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THERMOSENSITIVE POLY(N-ISOPROPYLACRYLAMIDE)-B-POLYCAPROLACTONE-B-POLY(N-ISOPROPYLACRYLAMIDE) TRIBLOCK COPOLYMERS PREPARED VIA ATOM TRANSFER RADICAL POLYMERIZATION FOR CONTROL OF CELL ADHESION AND DETACHMENT

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