SYNTHESIS OF A-RING-SUBSTITUTED 5,6,8,12B-TETRAHYDROISOINDOLO[1,2-A]ISOQUINOLIN-8-ONES

The synthesis of 4,5,8,12b-tetrahydroisoindolo[1,2-a]isoquinolin-8-ones is reviewed The unsubstituted parent compound, a series of fourteen A-ring-substituted derivatives, most of them new, and some of their doubly benzylic, 12b-hydroxylated oxidation products were synthesized. Unusual features of t...

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Autores principales: CASTRO-CASTILLO,VICENTE, REBOLLEDO-FUENTES,MARCO, CASSELS,BRUCE K
Lenguaje:English
Publicado: Sociedad Chilena de Química 2009
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400021
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Sumario:The synthesis of 4,5,8,12b-tetrahydroisoindolo[1,2-a]isoquinolin-8-ones is reviewed The unsubstituted parent compound, a series of fourteen A-ring-substituted derivatives, most of them new, and some of their doubly benzylic, 12b-hydroxylated oxidation products were synthesized. Unusual features of their reactivity are briefy discussed.