ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS

In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of tola, Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and me...

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Autores principales:	ZAMPINI,IRIS CATIANA, ISLA,MARÍA INÉS, SCHMEDA-HIRSCHMANN,GUILLERMO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Baccharis incarum Asteraceae infusion HPLC-MS polyphenols antimicrobial activity antioxidant
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400035
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spelling	oai:scielo:S0717-970720090004000352010-04-15ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINSZAMPINI,IRIS CATIANAISLA,MARÍA INÉSSCHMEDA-HIRSCHMANN,GUILLERMO Baccharis incarum Asteraceae infusion HPLC-MS polyphenols antimicrobial activity antioxidant In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of tola, Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS+ autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identifed as chlorogenic acid, 3,4,5,7-tetrahydroxyfavone; dicaffeoyl quinic acid; 3,4,5,7-tetrahydroxy-3,6-dimethoxyfavone; 3,4,5,7-tetrahydroxy-3,6,8-trimethoxy favone, 4,5,7-trihydroxy-3,3,6,8-tetramethoxyfavone and 4,5-dihydroxy-3,3,6,7,8-pentamethoxyfavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the frst report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC50 values of 1 to 10 µg/ml. The isolated favones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400035en10.4067/S0717-97072009000400035
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Baccharis incarum Asteraceae infusion HPLC-MS polyphenols antimicrobial activity antioxidant
spellingShingle	Baccharis incarum Asteraceae infusion HPLC-MS polyphenols antimicrobial activity antioxidant ZAMPINI,IRIS CATIANA ISLA,MARÍA INÉS SCHMEDA-HIRSCHMANN,GUILLERMO ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS
description	In the traditional medicine of the South American highlands, the infusion and decoction of aerial parts of tola, Baccharis incarum (Wedd.) Perkins (Asteraceae) is orally taken as an antiseptic, antipyretic and digestive or externally applied to relieve pain and infammation. A plant infusion and methanolic (MeOH) extract of the aerial parts were compared for main constituents by HPLC-MS as well as assessed for antimicrobial and free radical scavenging activities. Assay-guided fractionation of the polar extracts was carried out using the ABTS+ autographic as well as methicillin-resistant Staphylococcus aureus and Enterococcus faecalis bioautographic test. Seven compounds were isolated from the polar extracts and identifed as chlorogenic acid, 3,4,5,7-tetrahydroxyfavone; dicaffeoyl quinic acid; 3,4,5,7-tetrahydroxy-3,6-dimethoxyfavone; 3,4,5,7-tetrahydroxy-3,6,8-trimethoxy favone, 4,5,7-trihydroxy-3,3,6,8-tetramethoxyfavone and 4,5-dihydroxy-3,3,6,7,8-pentamethoxyfavone. The main constituents from the methanol extract and infusion were caffeic acid derivatives. This is the frst report on the constituents of B. incarum infusion and show clear differences with previous phytochemical studies on the same plant. All isolated compounds showed antioxidant activity with SC50 values of 1 to 10 µg/ml. The isolated favones were active against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis with MICs in the range 100 and >200 µg/ml.
author	ZAMPINI,IRIS CATIANA ISLA,MARÍA INÉS SCHMEDA-HIRSCHMANN,GUILLERMO
author_facet	ZAMPINI,IRIS CATIANA ISLA,MARÍA INÉS SCHMEDA-HIRSCHMANN,GUILLERMO
author_sort	ZAMPINI,IRIS CATIANA
title	ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS
title_short	ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS
title_full	ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS
title_fullStr	ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS
title_full_unstemmed	ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS
title_sort	antimicrobial and antioxidant compounds from the infusion and methanolic extract of baccharis incarum (wedd.) perkins
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400035
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ANTIMICROBIAL AND ANTIOXIDANT COMPOUNDS FROM THE INFUSION AND METHANOLIC EXTRACT OF Baccharis incarum (WEDD.) PERKINS

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