DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE

DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE

Spectrophotometric procedures are presented for the determination of the antiparkinsonism drug entacapone. The first method based on the formation of a coloured complex of entacapone with ferric chloride in ethanolic solutions. The coloured product is quantified spectrophotometrically at 665nm. The...

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Autores principales: GADALLAH MOHAMED,NASHWAH, SULTAN MOHAMED,MOHAMED
Lenguaje:English
Publicado: Sociedad Chilena de Química 2010
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100020
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spelling oai:scielo:S0717-970720100001000202010-04-29DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONEGADALLAH MOHAMED,NASHWAHSULTAN MOHAMED,MOHAMEDSpectrophotometric procedures are presented for the determination of the antiparkinsonism drug entacapone. The first method based on the formation of a coloured complex of entacapone with ferric chloride in ethanolic solutions. The coloured product is quantified spectrophotometrically at 665nm. The other Spectrophotometric method determine entacapone in presence of levodopa and carbidopa (which formulated with entacapone in stalevo tablets) by measuring the UV absorbance of entacapone either in zero order at 391nm or in the first order by measuring the amplitude between 360nm and 402nm without any interference from levodopa and carbidopa. HPLC method is described forthe separation and determination of entacapone, levodopa and carbidopa on Luna CN 150 x 4.6 column with UV detection at 390nm for entacapone and at 280nm for both levodopa and carbidopa.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.1 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100020en10.4067/S0717-97072010000100020
institution Scielo Chile
collection Scielo Chile
language English
description Spectrophotometric procedures are presented for the determination of the antiparkinsonism drug entacapone. The first method based on the formation of a coloured complex of entacapone with ferric chloride in ethanolic solutions. The coloured product is quantified spectrophotometrically at 665nm. The other Spectrophotometric method determine entacapone in presence of levodopa and carbidopa (which formulated with entacapone in stalevo tablets) by measuring the UV absorbance of entacapone either in zero order at 391nm or in the first order by measuring the amplitude between 360nm and 402nm without any interference from levodopa and carbidopa. HPLC method is described forthe separation and determination of entacapone, levodopa and carbidopa on Luna CN 150 x 4.6 column with UV detection at 390nm for entacapone and at 280nm for both levodopa and carbidopa.
author GADALLAH MOHAMED,NASHWAH
SULTAN MOHAMED,MOHAMED
spellingShingle GADALLAH MOHAMED,NASHWAH
SULTAN MOHAMED,MOHAMED
DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE
author_facet GADALLAH MOHAMED,NASHWAH
SULTAN MOHAMED,MOHAMED
author_sort GADALLAH MOHAMED,NASHWAH
title DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE
title_short DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE
title_full DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE
title_fullStr DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE
title_full_unstemmed DETERMINATION OF ANTIPARKINSONISM DRUG ENTACAPONE
title_sort determination of antiparkinsonism drug entacapone
publisher Sociedad Chilena de Química
publishDate 2010
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100020
work_keys_str_mv AT gadallahmohamednashwah determinationofantiparkinsonismdrugentacapone
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