A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION

A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7:...

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Autores principales:	PATIL,U. P, GANDHI,S. V, SENGAR,M. R, RAJMANE,V. S
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	High-performance thin-layer chromatography telmisartan atorvastatin calcium
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100022
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spelling	oai:scielo:S0717-970720100001000222010-04-29A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATIONPATIL,U. PGANDHI,S. VSENGAR,M. RRAJMANE,V. S High-performance thin-layer chromatography telmisartan atorvastatin calcium A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily presolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective cahbration plots were found to be linear over the range 200-1000 and 200-700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.1 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100022en10.4067/S0717-97072010000100022
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	High-performance thin-layer chromatography telmisartan atorvastatin calcium
spellingShingle	High-performance thin-layer chromatography telmisartan atorvastatin calcium PATIL,U. P GANDHI,S. V SENGAR,M. R RAJMANE,V. S A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
description	A simple, specific, accurate and precise high-performance thin-layer chromatographic method for analysis of Telmisartan and Atorvastatin calcium in fixed dose combination has been developed. The method uses aluminium plates coated with silica gel 60 F254 as stationary phase and toluene: methanol (7: 3, v/v) as mobile phase. Densitometric evaluation of the separated bands was performed at 280 nm. The two drugs were satisfactorily presolved with Rf values 0.50 ± 0.01 and 0.29 ± 0.00 for Telmisartan and Atorvastatin calcium, respectively. The respective cahbration plots were found to be linear over the range 200-1000 and 200-700 ng/band for Telmisartan and Atorvastatin calcium, respectively. This method has been successfully validated and applied for the analysis of drugs in pharmaceutical formulation.
author	PATIL,U. P GANDHI,S. V SENGAR,M. R RAJMANE,V. S
author_facet	PATIL,U. P GANDHI,S. V SENGAR,M. R RAJMANE,V. S
author_sort	PATIL,U. P
title	A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
title_short	A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
title_full	A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
title_fullStr	A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
title_full_unstemmed	A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION
title_sort	validated densitometric method for analysis of telmisartan and atorvastatin calcium in fixed dose combination
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100022
work_keys_str_mv	AT patilup avalidateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination AT gandhisv avalidateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination AT sengarmr avalidateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination AT rajmanevs avalidateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination AT patilup validateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination AT gandhisv validateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination AT sengarmr validateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination AT rajmanevs validateddensitometricmethodforanalysisoftelmisartanandatorvastatincalciuminfixeddosecombination
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A VALIDATED DENSITOMETRIC METHOD FOR ANALYSIS OF TELMISARTAN AND ATORVASTATIN CALCIUM IN FIXED DOSE COMBINATION

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