CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY

During our investigation in the area of epileptic drug discovery, we have identified that the available conventional antiepileptic drugs are effective in 60-80% patients and in specific type of seizures and having various undesirable side effects. But in present time aonew class aryl semicarbazone i...

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Autores principales:	SINGH,HEMENDRA PRATAP, CHAUHAN,C S, PANDEYA,S N, SHARMA,CHANDRA SHEKHAR
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	semicarbazide actophotometer antiepileptic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100024
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spelling	oai:scielo:S0717-970720100001000242010-04-29CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERYSINGH,HEMENDRA PRATAPCHAUHAN,C SPANDEYA,S NSHARMA,CHANDRA SHEKHAR semicarbazide actophotometer antiepileptic During our investigation in the area of epileptic drug discovery, we have identified that the available conventional antiepileptic drugs are effective in 60-80% patients and in specific type of seizures and having various undesirable side effects. But in present time aonew class aryl semicarbazone is emerged asonew pharmacophore in epileptic drug discovery having broad spectrum activity. On the bases of work done in this area we have applied hybridization of pharmacophore strategy of drug design and developed aonew pharmacophore. We have also designed a scheme for synthesizing such pharmacophore and performed their pharmacological screening for the protection of seizures, behavioral study and CNS activity. The compound 1-[1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl) allylidene]-4-(2-fluorophenyl) semicarbazide (8) emerged as the most active prototype molecule in all the models.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.1 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100024en10.4067/S0717-97072010000100024
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	semicarbazide actophotometer antiepileptic
spellingShingle	semicarbazide actophotometer antiepileptic SINGH,HEMENDRA PRATAP CHAUHAN,C S PANDEYA,S N SHARMA,CHANDRA SHEKHAR CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY
description	During our investigation in the area of epileptic drug discovery, we have identified that the available conventional antiepileptic drugs are effective in 60-80% patients and in specific type of seizures and having various undesirable side effects. But in present time aonew class aryl semicarbazone is emerged asonew pharmacophore in epileptic drug discovery having broad spectrum activity. On the bases of work done in this area we have applied hybridization of pharmacophore strategy of drug design and developed aonew pharmacophore. We have also designed a scheme for synthesizing such pharmacophore and performed their pharmacological screening for the protection of seizures, behavioral study and CNS activity. The compound 1-[1-(2,4-dihydroxyphenyl)-3-(2-hydroxyphenyl) allylidene]-4-(2-fluorophenyl) semicarbazide (8) emerged as the most active prototype molecule in all the models.
author	SINGH,HEMENDRA PRATAP CHAUHAN,C S PANDEYA,S N SHARMA,CHANDRA SHEKHAR
author_facet	SINGH,HEMENDRA PRATAP CHAUHAN,C S PANDEYA,S N SHARMA,CHANDRA SHEKHAR
author_sort	SINGH,HEMENDRA PRATAP
title	CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY
title_short	CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY
title_full	CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY
title_fullStr	CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY
title_full_unstemmed	CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY
title_sort	chalconsemicarbazone: a new scaffold for antiepileptic drug discovery
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000100024
work_keys_str_mv	AT singhhemendrapratap chalconsemicarbazoneanewscaffoldforantiepilepticdrugdiscovery AT chauhancs chalconsemicarbazoneanewscaffoldforantiepilepticdrugdiscovery AT pandeyasn chalconsemicarbazoneanewscaffoldforantiepilepticdrugdiscovery AT sharmachandrashekhar chalconsemicarbazoneanewscaffoldforantiepilepticdrugdiscovery
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CHALCONSEMICARBAZONE: A NEW SCAFFOLD FOR ANTIEPILEPTIC DRUG DISCOVERY

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