STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION

A simple, highly sensitive, isocratic stability indicating reversed phase-high performance liquid chromatography (RP-HPLC) method with UV detection at 247 nm was developed and validated for analysis of atorvastatin (AT). Retention time of the AT was found to be 4.02 min. A mobile phase consisting of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	MUSTAFA,GULAM, AZEEM,ADNAN, AHMAD,FARHAN J, KHAN,ZEENAT I, SHAKEEL,FAIYAZ, TALEGAONKAR,SUSHMA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	RP-HPLC atorvastatin nanoemulsion tablets ICH guidelines
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200008
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072010000200008
record_format	dspace
spelling	oai:scielo:S0717-970720100002000082010-09-06STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATIONMUSTAFA,GULAMAZEEM,ADNANAHMAD,FARHAN JKHAN,ZEENAT ISHAKEEL,FAIYAZTALEGAONKAR,SUSHMA RP-HPLC atorvastatin nanoemulsion tablets ICH guidelines A simple, highly sensitive, isocratic stability indicating reversed phase-high performance liquid chromatography (RP-HPLC) method with UV detection at 247 nm was developed and validated for analysis of atorvastatin (AT). Retention time of the AT was found to be 4.02 min. A mobile phase consisting of 0.05 M sodium phosphate buffer and methanol (3:7 v/v) pH 4.1 at flow rate of lµL/min was employed in this study. The calibration curves were linear with regression coefficient (r²) of 0.9997 ± 0.0014. The limits of detection (LOD) and the limits of quantification (LOQ) were found to be 0.20 and 0.60 µg/mL, respectively. The method was statistically validated in accordance with International conference on harmonization (ICH) guidelines. The proposed method was found sensitive, specific and was successfully applied for the estimation of atorvastatin in pharmaceutical formulations (bulk drug, tablet, nanoemulsion).info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200008en10.4067/S0717-97072010000200008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	RP-HPLC atorvastatin nanoemulsion tablets ICH guidelines
spellingShingle	RP-HPLC atorvastatin nanoemulsion tablets ICH guidelines MUSTAFA,GULAM AZEEM,ADNAN AHMAD,FARHAN J KHAN,ZEENAT I SHAKEEL,FAIYAZ TALEGAONKAR,SUSHMA STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
description	A simple, highly sensitive, isocratic stability indicating reversed phase-high performance liquid chromatography (RP-HPLC) method with UV detection at 247 nm was developed and validated for analysis of atorvastatin (AT). Retention time of the AT was found to be 4.02 min. A mobile phase consisting of 0.05 M sodium phosphate buffer and methanol (3:7 v/v) pH 4.1 at flow rate of lµL/min was employed in this study. The calibration curves were linear with regression coefficient (r²) of 0.9997 ± 0.0014. The limits of detection (LOD) and the limits of quantification (LOQ) were found to be 0.20 and 0.60 µg/mL, respectively. The method was statistically validated in accordance with International conference on harmonization (ICH) guidelines. The proposed method was found sensitive, specific and was successfully applied for the estimation of atorvastatin in pharmaceutical formulations (bulk drug, tablet, nanoemulsion).
author	MUSTAFA,GULAM AZEEM,ADNAN AHMAD,FARHAN J KHAN,ZEENAT I SHAKEEL,FAIYAZ TALEGAONKAR,SUSHMA
author_facet	MUSTAFA,GULAM AZEEM,ADNAN AHMAD,FARHAN J KHAN,ZEENAT I SHAKEEL,FAIYAZ TALEGAONKAR,SUSHMA
author_sort	MUSTAFA,GULAM
title	STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
title_short	STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
title_full	STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
title_fullStr	STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
title_full_unstemmed	STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION
title_sort	stability-indicating rp-hplc method for analysis of atorvastatin in bulk drug, marketed tablet and nanoemulsion formulation
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200008
work_keys_str_mv	AT mustafagulam stabilityindicatingrphplcmethodforanalysisofatorvastatininbulkdrugmarketedtabletandnanoemulsionformulation AT azeemadnan stabilityindicatingrphplcmethodforanalysisofatorvastatininbulkdrugmarketedtabletandnanoemulsionformulation AT ahmadfarhanj stabilityindicatingrphplcmethodforanalysisofatorvastatininbulkdrugmarketedtabletandnanoemulsionformulation AT khanzeenati stabilityindicatingrphplcmethodforanalysisofatorvastatininbulkdrugmarketedtabletandnanoemulsionformulation AT shakeelfaiyaz stabilityindicatingrphplcmethodforanalysisofatorvastatininbulkdrugmarketedtabletandnanoemulsionformulation AT talegaonkarsushma stabilityindicatingrphplcmethodforanalysisofatorvastatininbulkdrugmarketedtabletandnanoemulsionformulation
_version_	1718445425458937856

STABILITY-INDICATING RP-HPLC METHOD FOR ANALYSIS OF ATORVASTATIN IN BULK DRUG, MARKETED TABLET AND NANOEMULSION FORMULATION

Ejemplares similares