AUTOMATIC MULTISYRINGE FLOW INJECTION SYSTEM FOR THE SPECTROPHOTOMETRIC DETERMINATION OF TINIDAZOLE IN PHARMACEUTICAL PREPARATIONS
A multisyringe flow injection analysis (MSFIA) method for the determination of tinidazole (TNZ) in pharmaceutical preparations was developed. TNZ concentrations were determined by spectrophotometric detection at 374 nm wavelength using a light emitting diode (LED). The MSFIA parameters were optimize...
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| Autores principales: | , , , , , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2010
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200015 |
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| Sumario: | A multisyringe flow injection analysis (MSFIA) method for the determination of tinidazole (TNZ) in pharmaceutical preparations was developed. TNZ concentrations were determined by spectrophotometric detection at 374 nm wavelength using a light emitting diode (LED). The MSFIA parameters were optimized. Under the optimized experimental conditions, a linear dynamic range from 2 to 56 mg L-1 TNZ, a 3σ detection limit of 0.3 mg L-1, and a 10o quantification limit of 1.2 mg L-1 were obtained. The relative standard deviation (%R.S.D.) at 2, 28 and 56 mg L-1 was 2.3, 1.4 and 0.9%, respectively (n = 10). A sample throughput of 76 determinations/h was achieved. |
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