SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS

Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth...

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Autores principales:	ESPINOZA CATALÁN,LUIS, MADRID VILLEGAS,ALEJANDRO, TABORGA LIBER,LAUTARO, VILLENA GARCÍA,JOAN, CUELLAR FRITIS,MAURICIO, CARRASCO ALTAMIRANO,HÉCTOR
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Antiproliferative activity safrole derivatives synthesis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016
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spelling	oai:scielo:S0717-970720100002000162010-09-06SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLSESPINOZA CATALÁN,LUISMADRID VILLEGAS,ALEJANDROTABORGA LIBER,LAUTAROVILLENA GARCÍA,JOANCUELLAR FRITIS,MAURICIOCARRASCO ALTAMIRANO,HÉCTOR Antiproliferative activity safrole derivatives synthesis Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016en10.4067/S0717-97072010000200016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antiproliferative activity safrole derivatives synthesis
spellingShingle	Antiproliferative activity safrole derivatives synthesis ESPINOZA CATALÁN,LUIS MADRID VILLEGAS,ALEJANDRO TABORGA LIBER,LAUTARO VILLENA GARCÍA,JOAN CUELLAR FRITIS,MAURICIO CARRASCO ALTAMIRANO,HÉCTOR SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS
description	Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).
author	ESPINOZA CATALÁN,LUIS MADRID VILLEGAS,ALEJANDRO TABORGA LIBER,LAUTARO VILLENA GARCÍA,JOAN CUELLAR FRITIS,MAURICIO CARRASCO ALTAMIRANO,HÉCTOR
author_facet	ESPINOZA CATALÁN,LUIS MADRID VILLEGAS,ALEJANDRO TABORGA LIBER,LAUTARO VILLENA GARCÍA,JOAN CUELLAR FRITIS,MAURICIO CARRASCO ALTAMIRANO,HÉCTOR
author_sort	ESPINOZA CATALÁN,LUIS
title	SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS
title_short	SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS
title_full	SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS
title_fullStr	SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS
title_full_unstemmed	SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS
title_sort	synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016
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SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS

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