A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION

A simple, sensitive and validated HPLC method has been developed to determine valsartan and ramipril simultaneously in synthetic mixture. Chromatographic separation was achieved on a C-18 column using a mixture of acetonitrile and water in the ratio 55:45 (v/v), pH adjusted to 3.6 with 88% orthophos...

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Autores principales:	LAKSHMI,K. S, SIVASUBRAMANIAN,LAKSHMI
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	HPLC Valsartan Ramipril
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200017
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spelling	oai:scielo:S0717-970720100002000172010-09-06A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATIONLAKSHMI,K. SSIVASUBRAMANIAN,LAKSHMI HPLC Valsartan Ramipril A simple, sensitive and validated HPLC method has been developed to determine valsartan and ramipril simultaneously in synthetic mixture. Chromatographic separation was achieved on a C-18 column using a mixture of acetonitrile and water in the ratio 55:45 (v/v), pH adjusted to 3.6 with 88% orthophosphoric acid at a wavelength of 215 nm. Linearity of the method was found to be in the concentration range of 50-250 µg/ml for valsartan andl00-500 µg/ml for ramipril with correlation coefficient greater than 0.999. The total eluting time for the two components is less than five minutes. The method can be used for simultaneous determination of valsartan and ramipril.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200017en10.4067/S0717-97072010000200017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	HPLC Valsartan Ramipril
spellingShingle	HPLC Valsartan Ramipril LAKSHMI,K. S SIVASUBRAMANIAN,LAKSHMI A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION
description	A simple, sensitive and validated HPLC method has been developed to determine valsartan and ramipril simultaneously in synthetic mixture. Chromatographic separation was achieved on a C-18 column using a mixture of acetonitrile and water in the ratio 55:45 (v/v), pH adjusted to 3.6 with 88% orthophosphoric acid at a wavelength of 215 nm. Linearity of the method was found to be in the concentration range of 50-250 µg/ml for valsartan andl00-500 µg/ml for ramipril with correlation coefficient greater than 0.999. The total eluting time for the two components is less than five minutes. The method can be used for simultaneous determination of valsartan and ramipril.
author	LAKSHMI,K. S SIVASUBRAMANIAN,LAKSHMI
author_facet	LAKSHMI,K. S SIVASUBRAMANIAN,LAKSHMI
author_sort	LAKSHMI,K. S
title	A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION
title_short	A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION
title_full	A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION
title_fullStr	A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION
title_full_unstemmed	A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION
title_sort	stability indicating hplc method for the simultaneous determination of valsartan and ramipril in binary combination
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200017
work_keys_str_mv	AT lakshmiks astabilityindicatinghplcmethodforthesimultaneousdeterminationofvalsartanandramiprilinbinarycombination AT sivasubramanianlakshmi astabilityindicatinghplcmethodforthesimultaneousdeterminationofvalsartanandramiprilinbinarycombination AT lakshmiks stabilityindicatinghplcmethodforthesimultaneousdeterminationofvalsartanandramiprilinbinarycombination AT sivasubramanianlakshmi stabilityindicatinghplcmethodforthesimultaneousdeterminationofvalsartanandramiprilinbinarycombination
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A STABILITY INDICATING HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF VALSARTAN AND RAMIPRIL IN BINARY COMBINATION

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