ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY

Cyclic Voltammetry (CV) and electrón spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process involving protonation of the nitro group due to the presence of an acidic protón i...

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Autores principales:	ARAVENA C,MARÍA, FIGUEROA,ROBERTO, OLEA-AZAR,CLAUDIO, ARÁN,VICENTE J
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	ESR Chagas' disease ORAC Cyclic Voltammetry Nitro compounds
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200022
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spelling	oai:scielo:S0717-970720100002000222010-09-06ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITYARAVENA C,MARÍAFIGUEROA,ROBERTOOLEA-AZAR,CLAUDIOARÁN,VICENTE J ESR Chagas' disease ORAC Cyclic Voltammetry Nitro compounds Cyclic Voltammetry (CV) and electrón spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process involving protonation of the nitro group due to the presence of an acidic protón in the structure of the nitro compound was observed in the first step of an ECErev reduction mechanism. ESR spectra of the free radicals obtained by electrochemical reduction in situ were characterized and analyzed. The ESR spectra showed three different hyperfine patterns for both families of compounds. In order to evaluate the free radical scavenger properties of these nitrocompounds we carried out ORAC-Fl (Oxygen Radical Antioxidant Capacity) assay. These derivatives showed a low antioxidant capacity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200022en10.4067/S0717-97072010000200022
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	ESR Chagas' disease ORAC Cyclic Voltammetry Nitro compounds
spellingShingle	ESR Chagas' disease ORAC Cyclic Voltammetry Nitro compounds ARAVENA C,MARÍA FIGUEROA,ROBERTO OLEA-AZAR,CLAUDIO ARÁN,VICENTE J ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
description	Cyclic Voltammetry (CV) and electrón spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process involving protonation of the nitro group due to the presence of an acidic protón in the structure of the nitro compound was observed in the first step of an ECErev reduction mechanism. ESR spectra of the free radicals obtained by electrochemical reduction in situ were characterized and analyzed. The ESR spectra showed three different hyperfine patterns for both families of compounds. In order to evaluate the free radical scavenger properties of these nitrocompounds we carried out ORAC-Fl (Oxygen Radical Antioxidant Capacity) assay. These derivatives showed a low antioxidant capacity.
author	ARAVENA C,MARÍA FIGUEROA,ROBERTO OLEA-AZAR,CLAUDIO ARÁN,VICENTE J
author_facet	ARAVENA C,MARÍA FIGUEROA,ROBERTO OLEA-AZAR,CLAUDIO ARÁN,VICENTE J
author_sort	ARAVENA C,MARÍA
title	ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
title_short	ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
title_full	ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
title_fullStr	ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
title_full_unstemmed	ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY
title_sort	esr, electrochemical and orac studies of nitro compounds with potential antiprotozoal actvity
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200022
work_keys_str_mv	AT aravenacmaria esrelectrochemicalandoracstudiesofnitrocompoundswithpotentialantiprotozoalactvity AT figueroaroberto esrelectrochemicalandoracstudiesofnitrocompoundswithpotentialantiprotozoalactvity AT oleaazarclaudio esrelectrochemicalandoracstudiesofnitrocompoundswithpotentialantiprotozoalactvity AT aranvicentej esrelectrochemicalandoracstudiesofnitrocompoundswithpotentialantiprotozoalactvity
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ESR, ELECTROCHEMICAL AND ORAC STUDIES OF NITRO COMPOUNDS WITH POTENTIAL ANTIPROTOZOAL ACTVITY

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