SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

A simple reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of rosiglitazone (RGL) and gliclazide (GLC) in puré and pharmaceutical dosage forms. Aphenomenex Gemini reverse phase C column (150x4.6mm i.d., 5µ) was used with a mobile phase cont...

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Autores principales:	LAKSHMI,K.S, RAJESH,T
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Rosiglitazone Gliclazide RP-HPLC validation Pharmaceutical dosage forms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200023
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spelling	oai:scielo:S0717-970720100002000232010-09-06SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHYLAKSHMI,K.SRAJESH,T Rosiglitazone Gliclazide RP-HPLC validation Pharmaceutical dosage forms A simple reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of rosiglitazone (RGL) and gliclazide (GLC) in puré and pharmaceutical dosage forms. Aphenomenex Gemini reverse phase C column (150x4.6mm i.d., 5µ) was used with a mobile phase containing a mixture of acetonitrile and water (pH 3 adjusted with ortho phosphoric acid) in the ratio of 70: 30. The flow rate was 0.6mL/min. and effluents were monitored at 250nm and eluted at 2.41min. (RGL) and 5.22min. (GLC). Calibration curve was plotted with a range from 0.025-2.5µg/mL for RGL and 0.08 to 8µg/mL for GLC. The assay was validated for the parameters like accuracy (>97.87% recovery), precision (intra-day and inter-day with %RSD < 2), robustness and system suitability parameters. Henee the method was found to suitable for the routine quality control of the drugs in puré and pharmaceutical dosage forms.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200023en10.4067/S0717-97072010000200023
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Rosiglitazone Gliclazide RP-HPLC validation Pharmaceutical dosage forms
spellingShingle	Rosiglitazone Gliclazide RP-HPLC validation Pharmaceutical dosage forms LAKSHMI,K.S RAJESH,T SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
description	A simple reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of rosiglitazone (RGL) and gliclazide (GLC) in puré and pharmaceutical dosage forms. Aphenomenex Gemini reverse phase C column (150x4.6mm i.d., 5µ) was used with a mobile phase containing a mixture of acetonitrile and water (pH 3 adjusted with ortho phosphoric acid) in the ratio of 70: 30. The flow rate was 0.6mL/min. and effluents were monitored at 250nm and eluted at 2.41min. (RGL) and 5.22min. (GLC). Calibration curve was plotted with a range from 0.025-2.5µg/mL for RGL and 0.08 to 8µg/mL for GLC. The assay was validated for the parameters like accuracy (>97.87% recovery), precision (intra-day and inter-day with %RSD < 2), robustness and system suitability parameters. Henee the method was found to suitable for the routine quality control of the drugs in puré and pharmaceutical dosage forms.
author	LAKSHMI,K.S RAJESH,T
author_facet	LAKSHMI,K.S RAJESH,T
author_sort	LAKSHMI,K.S
title	SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
title_short	SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
title_full	SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
title_fullStr	SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
title_full_unstemmed	SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
title_sort	simultaneous determination of rosiglitazone and gliclazide in pharmaceutical dosage forms by high performance liquid chromatography
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200023
work_keys_str_mv	AT lakshmiks simultaneousdeterminationofrosiglitazoneandgliclazideinpharmaceuticaldosageformsbyhighperformanceliquidchromatography AT rajesht simultaneousdeterminationofrosiglitazoneandgliclazideinpharmaceuticaldosageformsbyhighperformanceliquidchromatography
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SIMULTANEOUS DETERMINATION OF ROSIGLITAZONE AND GLICLAZIDE IN PHARMACEUTICAL DOSAGE FORMS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

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