SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES

A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Gram-positive and Gram-negative bacteria. The synthesized Mannich bases were characterized by elemental and spectral analysis. The modeling anti-bacte...

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Autores principales:	DAS MANIKPURI,ANJU, JOSHI,SHEELA, KHADIKAR,PADMAKAR V
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Glutarimides sulfonamides Mannich bases antimicrobial activity QSAR
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300001
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spelling	oai:scielo:S0717-970720100003000012011-01-25SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDESDAS MANIKPURI,ANJUJOSHI,SHEELAKHADIKAR,PADMAKAR V Glutarimides sulfonamides Mannich bases antimicrobial activity QSAR A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Gram-positive and Gram-negative bacteria. The synthesized Mannich bases were characterized by elemental and spectral analysis. The modeling anti-bacterial activities of these newly synthesized Mannich bases against six bacteria was attempted employing ¹H NMR chemical shift, physicochemical properties and topological indices as the correlating parameters. Our results, based on Quantitative Structure-Activity Relationships (QSARs), have indicated that statistically significant models are obtained for modeling the anti-bacterial activities The results are discussed critically using a variety of statistical parameters.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300001en10.4067/S0717-97072010000300001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Glutarimides sulfonamides Mannich bases antimicrobial activity QSAR
spellingShingle	Glutarimides sulfonamides Mannich bases antimicrobial activity QSAR DAS MANIKPURI,ANJU JOSHI,SHEELA KHADIKAR,PADMAKAR V SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
description	A series of forty Mannich bases of glutarimides with sulfonamides and secondary amines were synthesized and evaluated in vitro against six pathogenic Gram-positive and Gram-negative bacteria. The synthesized Mannich bases were characterized by elemental and spectral analysis. The modeling anti-bacterial activities of these newly synthesized Mannich bases against six bacteria was attempted employing ¹H NMR chemical shift, physicochemical properties and topological indices as the correlating parameters. Our results, based on Quantitative Structure-Activity Relationships (QSARs), have indicated that statistically significant models are obtained for modeling the anti-bacterial activities The results are discussed critically using a variety of statistical parameters.
author	DAS MANIKPURI,ANJU JOSHI,SHEELA KHADIKAR,PADMAKAR V
author_facet	DAS MANIKPURI,ANJU JOSHI,SHEELA KHADIKAR,PADMAKAR V
author_sort	DAS MANIKPURI,ANJU
title	SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
title_short	SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
title_full	SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
title_fullStr	SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
title_full_unstemmed	SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES
title_sort	synthetic, spectral, antimicrobial and qsar studies on novel mannich bases of glutarimides
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300001
work_keys_str_mv	AT dasmanikpurianju syntheticspectralantimicrobialandqsarstudiesonnovelmannichbasesofglutarimides AT joshisheela syntheticspectralantimicrobialandqsarstudiesonnovelmannichbasesofglutarimides AT khadikarpadmakarv syntheticspectralantimicrobialandqsarstudiesonnovelmannichbasesofglutarimides
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SYNTHETIC, SPECTRAL, ANTIMICROBIAL AND QSAR STUDIES ON NOVEL MANNICH BASES OF GLUTARIMIDES

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