THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei

Parasites from the Trypanosomatidae family cause different illnesses in human and animals. Drugs currently in use against them have limited efficacy and high toxicity, therefore is very important that scientists continue their efforts to look for new targets for the treatment of these diseases. Tryp...

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Autores principales:	CORDERO DE TROCONIS,MARYI, COLMAN,TRINA, LEDEZMA DE RUIZ,MARGOT
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Trypanosome Brucei Homology Modeling MODELLER
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300003
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spelling	oai:scielo:S0717-970720100003000032011-01-25THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome bruceiCORDERO DE TROCONIS,MARYICOLMAN,TRINALEDEZMA DE RUIZ,MARGOT Trypanosome Brucei Homology Modeling MODELLER Parasites from the Trypanosomatidae family cause different illnesses in human and animals. Drugs currently in use against them have limited efficacy and high toxicity, therefore is very important that scientists continue their efforts to look for new targets for the treatment of these diseases. Trypanosome brucei is the causal agent of African trypanosomiasis (sleeping sickness) in human and animals, and is one of the trypanosome species that are actively investigated. Trypanosomes in the blood depend entirely from the glycolisis in order to obtain energy, so this is one of the possible points of attack. The aldolase fructose biphosphate seems to be until now the regulator of the glycolisis so its study is very important. The modeled three-dimensional structure of aldolase fructose biphosphate from Trypanosome brucei was obtained using the program Modeller based on the sequence previously published by Clayton. This modeled structure will help as a starting point for future rational chemotherapy studies, and the methodology described could be used for other enzymes of unknown three dimensional structures.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300003en10.4067/S0717-97072010000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Trypanosome Brucei Homology Modeling MODELLER
spellingShingle	Trypanosome Brucei Homology Modeling MODELLER CORDERO DE TROCONIS,MARYI COLMAN,TRINA LEDEZMA DE RUIZ,MARGOT THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei
description	Parasites from the Trypanosomatidae family cause different illnesses in human and animals. Drugs currently in use against them have limited efficacy and high toxicity, therefore is very important that scientists continue their efforts to look for new targets for the treatment of these diseases. Trypanosome brucei is the causal agent of African trypanosomiasis (sleeping sickness) in human and animals, and is one of the trypanosome species that are actively investigated. Trypanosomes in the blood depend entirely from the glycolisis in order to obtain energy, so this is one of the possible points of attack. The aldolase fructose biphosphate seems to be until now the regulator of the glycolisis so its study is very important. The modeled three-dimensional structure of aldolase fructose biphosphate from Trypanosome brucei was obtained using the program Modeller based on the sequence previously published by Clayton. This modeled structure will help as a starting point for future rational chemotherapy studies, and the methodology described could be used for other enzymes of unknown three dimensional structures.
author	CORDERO DE TROCONIS,MARYI COLMAN,TRINA LEDEZMA DE RUIZ,MARGOT
author_facet	CORDERO DE TROCONIS,MARYI COLMAN,TRINA LEDEZMA DE RUIZ,MARGOT
author_sort	CORDERO DE TROCONIS,MARYI
title	THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei
title_short	THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei
title_full	THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei
title_fullStr	THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei
title_full_unstemmed	THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei
title_sort	theoretical model of aldolase fructose 1,6 biphosphate from trypanosome brucei
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300003
work_keys_str_mv	AT corderodetroconismaryi theoreticalmodelofaldolasefructose16biphosphatefromtrypanosomebrucei AT colmantrina theoreticalmodelofaldolasefructose16biphosphatefromtrypanosomebrucei AT ledezmaderuizmargot theoreticalmodelofaldolasefructose16biphosphatefromtrypanosomebrucei
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THEORETICAL MODEL OF ALDOLASE FRUCTOSE 1,6 BIPHOSPHATE FROM Trypanosome brucei

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