SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL

In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-positio...

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Autores principales:	HUSAIN,ASIF, MAAZ,MOHAMMAD, AHMAD ANSARI,KHURSHEED, AHMAD,AUSAF, RASHID,MOHD
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Mannich base resorcinol antibacterial antifungal
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300012
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spelling	oai:scielo:S0717-970720100003000122011-01-25SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOLHUSAIN,ASIFMAAZ,MOHAMMADAHMAD ANSARI,KHURSHEEDAHMAD,AUSAFRASHID,MOHD Mannich base resorcinol antibacterial antifungal In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-position into the aromatic ring. The compounds were characterized on the basis of elemental analysis as well as ¹H NMR and Mass spectral data. The antibacterial and antifungal activities of the title compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus flavus and Candida albicans. Ofloxacin and voriconazole at 20 ug/mL were used as standard drugs for antibacterial and antifungal activities, respectively.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300012en10.4067/S0717-97072010000300012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mannich base resorcinol antibacterial antifungal
spellingShingle	Mannich base resorcinol antibacterial antifungal HUSAIN,ASIF MAAZ,MOHAMMAD AHMAD ANSARI,KHURSHEED AHMAD,AUSAF RASHID,MOHD SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL
description	In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-position into the aromatic ring. The compounds were characterized on the basis of elemental analysis as well as ¹H NMR and Mass spectral data. The antibacterial and antifungal activities of the title compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus flavus and Candida albicans. Ofloxacin and voriconazole at 20 ug/mL were used as standard drugs for antibacterial and antifungal activities, respectively.
author	HUSAIN,ASIF MAAZ,MOHAMMAD AHMAD ANSARI,KHURSHEED AHMAD,AUSAF RASHID,MOHD
author_facet	HUSAIN,ASIF MAAZ,MOHAMMAD AHMAD ANSARI,KHURSHEED AHMAD,AUSAF RASHID,MOHD
author_sort	HUSAIN,ASIF
title	SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL
title_short	SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL
title_full	SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL
title_fullStr	SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL
title_full_unstemmed	SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL
title_sort	synthesis and microbiological evaluation of mannich bases derived from 4,6-diacetylresorcinol
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300012
work_keys_str_mv	AT husainasif synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT maazmohammad synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT ahmadansarikhursheed synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT ahmadausaf synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT rashidmohd synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol
_version_	1718445432074403840

SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL

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