SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES

Some 4-[{1-(substituted)methylidine}-amino]-3-(4-pyridyl)-5-mercapto-4H-1,2,4-triazol (3a- 3f) and N-[5-(4-substituted)-1H-1,2,3-triazol-1-yl] isonicotinamide derivatives (5a- 5e) were synthesized by a sequence of reactions starting from isonicotinic acid hydrazide and is illustrated in scheme 1 and...

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Autores principales:	MISHRA,RAVINESH, KUMAR,RAJIV, KUMAR,SURESH, MAJEED,JASEELA, RASHID,MOHD, SHARMA,SAMEER
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Triazole derivatives Antimicrobial activity Ciprofloxacin Fluconazole
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300019
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spelling	oai:scielo:S0717-970720100003000192011-01-25SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVESMISHRA,RAVINESHKUMAR,RAJIVKUMAR,SURESHMAJEED,JASEELARASHID,MOHDSHARMA,SAMEER Triazole derivatives Antimicrobial activity Ciprofloxacin Fluconazole Some 4-[{1-(substituted)methylidine}-amino]-3-(4-pyridyl)-5-mercapto-4H-1,2,4-triazol (3a- 3f) and N-[5-(4-substituted)-1H-1,2,3-triazol-1-yl] isonicotinamide derivatives (5a- 5e) were synthesized by a sequence of reactions starting from isonicotinic acid hydrazide and is illustrated in scheme 1 and 2. The antibacterial and antifungal activities of newly synthesized compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus niger and Candida albicans. Ciprofloxacin and Fluconazole at 50 µg/mL were used as standard drugs for antibacterial and antifungal activities, respectively. All the synthesized compounds showed significant activity against various microorganisms.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300019en10.4067/S0717-97072010000300019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Triazole derivatives Antimicrobial activity Ciprofloxacin Fluconazole
spellingShingle	Triazole derivatives Antimicrobial activity Ciprofloxacin Fluconazole MISHRA,RAVINESH KUMAR,RAJIV KUMAR,SURESH MAJEED,JASEELA RASHID,MOHD SHARMA,SAMEER SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES
description	Some 4-[{1-(substituted)methylidine}-amino]-3-(4-pyridyl)-5-mercapto-4H-1,2,4-triazol (3a- 3f) and N-[5-(4-substituted)-1H-1,2,3-triazol-1-yl] isonicotinamide derivatives (5a- 5e) were synthesized by a sequence of reactions starting from isonicotinic acid hydrazide and is illustrated in scheme 1 and 2. The antibacterial and antifungal activities of newly synthesized compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus niger and Candida albicans. Ciprofloxacin and Fluconazole at 50 µg/mL were used as standard drugs for antibacterial and antifungal activities, respectively. All the synthesized compounds showed significant activity against various microorganisms.
author	MISHRA,RAVINESH KUMAR,RAJIV KUMAR,SURESH MAJEED,JASEELA RASHID,MOHD SHARMA,SAMEER
author_facet	MISHRA,RAVINESH KUMAR,RAJIV KUMAR,SURESH MAJEED,JASEELA RASHID,MOHD SHARMA,SAMEER
author_sort	MISHRA,RAVINESH
title	SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES
title_short	SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES
title_full	SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES
title_fullStr	SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES
title_full_unstemmed	SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES
title_sort	synthesis and in vitro antimicrobial activity of some triazole derivatives
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300019
work_keys_str_mv	AT mishraravinesh synthesisandinvitroantimicrobialactivityofsometriazolederivatives AT kumarrajiv synthesisandinvitroantimicrobialactivityofsometriazolederivatives AT kumarsuresh synthesisandinvitroantimicrobialactivityofsometriazolederivatives AT majeedjaseela synthesisandinvitroantimicrobialactivityofsometriazolederivatives AT rashidmohd synthesisandinvitroantimicrobialactivityofsometriazolederivatives AT sharmasameer synthesisandinvitroantimicrobialactivityofsometriazolederivatives
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SYNTHESIS AND In vitro ANTIMICROBIAL ACTIVITY OF SOME TRIAZOLE DERIVATIVES

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