SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY

A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and ¹HNMR spectroscopy. All these Mannich...

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Autores principales:	RAJASEKARAN,AIYALU, PERIYASAMY,MUTHUSAMY
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Mannich bases benztriazoles hepatoprotective Serum Glutamate Oxaloacetate Transaminase Serum Glutamate Pyruvate Transaminase Alkaline Phosphatase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300021
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spelling	oai:scielo:S0717-970720100003000212011-01-25SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETYRAJASEKARAN,AIYALUPERIYASAMY,MUTHUSAMY Mannich bases benztriazoles hepatoprotective Serum Glutamate Oxaloacetate Transaminase Serum Glutamate Pyruvate Transaminase Alkaline Phosphatase A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and ¹HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) protected significantly the animals from carbon tetrachloride induced hepatotoxicity. Compound 4 N-morpholinyl methyl benztriazole exhibited significant activity comparable to that of standard drug silymarin.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300021en10.4067/S0717-97072010000300021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mannich bases benztriazoles hepatoprotective Serum Glutamate Oxaloacetate Transaminase Serum Glutamate Pyruvate Transaminase Alkaline Phosphatase
spellingShingle	Mannich bases benztriazoles hepatoprotective Serum Glutamate Oxaloacetate Transaminase Serum Glutamate Pyruvate Transaminase Alkaline Phosphatase RAJASEKARAN,AIYALU PERIYASAMY,MUTHUSAMY SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY
description	A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and ¹HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) protected significantly the animals from carbon tetrachloride induced hepatotoxicity. Compound 4 N-morpholinyl methyl benztriazole exhibited significant activity comparable to that of standard drug silymarin.
author	RAJASEKARAN,AIYALU PERIYASAMY,MUTHUSAMY
author_facet	RAJASEKARAN,AIYALU PERIYASAMY,MUTHUSAMY
author_sort	RAJASEKARAN,AIYALU
title	SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY
title_short	SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY
title_full	SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY
title_fullStr	SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY
title_full_unstemmed	SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY
title_sort	synthesis and evaluation of hepatoprotective activity of some new mannich bases bearing benztriazole moiety
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300021
work_keys_str_mv	AT rajasekaranaiyalu synthesisandevaluationofhepatoprotectiveactivityofsomenewmannichbasesbearingbenztriazolemoiety AT periyasamymuthusamy synthesisandevaluationofhepatoprotectiveactivityofsomenewmannichbasesbearingbenztriazolemoiety
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SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY

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