SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES

The quinoxaline derivatives (i-v) were synthesized through cyclization-oxidation of a- bromo carbonyl compounds with o-phenyl diamines (7a and 10a) and further coupling at 6-position via Suzuki reaction using PdCl2 (dppf).DCM, ter. BuNH2, Na2CO3 in IPA, H2O refluxed for 16 h. As the results of antib...

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Autores principales:	JAYACHANDRA REDDY,B, SOMASEKHARA REDDY,M.C
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	Quinoxaline Suzuki Coupling microwave Bacillus spericus Escherichia coli
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000400016
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spelling	oai:scielo:S0717-970720100004000162011-05-25SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINESJAYACHANDRA REDDY,BSOMASEKHARA REDDY,M.C Quinoxaline Suzuki Coupling microwave Bacillus spericus Escherichia coli The quinoxaline derivatives (i-v) were synthesized through cyclization-oxidation of a- bromo carbonyl compounds with o-phenyl diamines (7a and 10a) and further coupling at 6-position via Suzuki reaction using PdCl2 (dppf).DCM, ter. BuNH2, Na2CO3 in IPA, H2O refluxed for 16 h. As the results of antibacterial screening tests done by paper disc method, quinoxaline derivatives (i) and (v) revealed significant inhibition zone on Bacillus spericus and quinoxaline derivatives (iii) and (v) on Escherichia coli cultures.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.4 20102010-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000400016en10.4067/S0717-97072010000400016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Quinoxaline Suzuki Coupling microwave Bacillus spericus Escherichia coli
spellingShingle	Quinoxaline Suzuki Coupling microwave Bacillus spericus Escherichia coli JAYACHANDRA REDDY,B SOMASEKHARA REDDY,M.C SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES
description	The quinoxaline derivatives (i-v) were synthesized through cyclization-oxidation of a- bromo carbonyl compounds with o-phenyl diamines (7a and 10a) and further coupling at 6-position via Suzuki reaction using PdCl2 (dppf).DCM, ter. BuNH2, Na2CO3 in IPA, H2O refluxed for 16 h. As the results of antibacterial screening tests done by paper disc method, quinoxaline derivatives (i) and (v) revealed significant inhibition zone on Bacillus spericus and quinoxaline derivatives (iii) and (v) on Escherichia coli cultures.
author	JAYACHANDRA REDDY,B SOMASEKHARA REDDY,M.C
author_facet	JAYACHANDRA REDDY,B SOMASEKHARA REDDY,M.C
author_sort	JAYACHANDRA REDDY,B
title	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES
title_short	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES
title_full	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES
title_fullStr	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES
title_full_unstemmed	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES
title_sort	synthesis, characterization and antibacterial evaluation of few 2, 3-substituted quinoxalines
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000400016
work_keys_str_mv	AT jayachandrareddyb synthesischaracterizationandantibacterialevaluationoffew23substitutedquinoxalines AT somasekharareddymc synthesischaracterizationandantibacterialevaluationoffew23substitutedquinoxalines
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SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF FEW 2, 3-SUBSTITUTED QUINOXALINES

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