UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID

In this paper, psyllium (Psy) and acrylamide (AAm) based superabsorbent, synthesized using potassium persulphate (KPS) as an initiator and hexamethylene tetramine (HTMA) as a crosslinker, has been investigated for its swelling behaviour in distilled water as a function of time, temperature and pH. T...

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Autores principales:	KUMAR,KIRAN, KAITH,B. S, MITTAL,HEMANT
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2010
Materias:	psyllium acrylamide 5-amino salicylic acid drug delivery superabsorbent
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000400025
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spelling	oai:scielo:S0717-970720100004000252011-05-25UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACIDKUMAR,KIRANKAITH,B. SMITTAL,HEMANT psyllium acrylamide 5-amino salicylic acid drug delivery superabsorbent In this paper, psyllium (Psy) and acrylamide (AAm) based superabsorbent, synthesized using potassium persulphate (KPS) as an initiator and hexamethylene tetramine (HTMA) as a crosslinker, has been investigated for its swelling behaviour in distilled water as a function of time, temperature and pH. The hydrogel has further been applied for controlled delivery of 5-amino salicylic acid (5-ASA) under different pH conditions at 37 oc. It has been found to show Fickian type mechanism as the drug release showed diffusion coefficient less than 0.50 for all the pH conditions.The gel characteristic constant has been found to show 6.9 x 10², 20.61 X 10² and 33.4 x 10² values for pH 4.0, 7.0 and 9.2, respectively. The initial diffusion coefficient has been found to show greater values than late diffusion coefficient confirming greater release at the early stages of the drug release than that in the late stages.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.4 20102010-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000400025en10.4067/S0717-97072010000400025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	psyllium acrylamide 5-amino salicylic acid drug delivery superabsorbent
spellingShingle	psyllium acrylamide 5-amino salicylic acid drug delivery superabsorbent KUMAR,KIRAN KAITH,B. S MITTAL,HEMANT UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID
description	In this paper, psyllium (Psy) and acrylamide (AAm) based superabsorbent, synthesized using potassium persulphate (KPS) as an initiator and hexamethylene tetramine (HTMA) as a crosslinker, has been investigated for its swelling behaviour in distilled water as a function of time, temperature and pH. The hydrogel has further been applied for controlled delivery of 5-amino salicylic acid (5-ASA) under different pH conditions at 37 oc. It has been found to show Fickian type mechanism as the drug release showed diffusion coefficient less than 0.50 for all the pH conditions.The gel characteristic constant has been found to show 6.9 x 10², 20.61 X 10² and 33.4 x 10² values for pH 4.0, 7.0 and 9.2, respectively. The initial diffusion coefficient has been found to show greater values than late diffusion coefficient confirming greater release at the early stages of the drug release than that in the late stages.
author	KUMAR,KIRAN KAITH,B. S MITTAL,HEMANT
author_facet	KUMAR,KIRAN KAITH,B. S MITTAL,HEMANT
author_sort	KUMAR,KIRAN
title	UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID
title_short	UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID
title_full	UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID
title_fullStr	UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID
title_full_unstemmed	UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID
title_sort	utilization of acrylamide and natural polysaccharide based polymeric networks in ph controlled release of 5-amino salicylic acid
publisher	Sociedad Chilena de Química
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000400025
work_keys_str_mv	AT kumarkiran utilizationofacrylamideandnaturalpolysaccharidebasedpolymericnetworksinphcontrolledreleaseof5aminosalicylicacid AT kaithbs utilizationofacrylamideandnaturalpolysaccharidebasedpolymericnetworksinphcontrolledreleaseof5aminosalicylicacid AT mittalhemant utilizationofacrylamideandnaturalpolysaccharidebasedpolymericnetworksinphcontrolledreleaseof5aminosalicylicacid
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UTILIZATION OF ACRYLAMIDE AND NATURAL POLYSACCHARIDE BASED POLYMERIC NETWORKS IN PH CONTROLLED RELEASE OF 5-AMINO SALICYLIC ACID

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