SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE

A convenient ultrasound assisted synthesis of new anti-bacterial N-benzylidene-N'-(1-methyl-2, 2-dioxo-2,3-dihydro-1H-2λ6-benzo[c][1,2]thiazin-4-ylidene)-hydrazines from methyl anthranilate is reported. Methyl anthranilate was reacted with methane sulfonyl chloride, followed by N-alkyl...

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Autores principales:	SHAFIQ,MUHAMMAD, ZIA-UR-REHMAN,MUHAMMAD, ULLAH KHAN,ISLAM, NADEEM ARSHAD,MUHAMMAD, AHMED KHAN,SIRAJ
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	2,1-Benzothiazine 2,2-dioxides Schiff bases Anti-bacterial activity Methyl anthranilate
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100001
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spelling	oai:scielo:S0717-970720110001000012011-06-17SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATESHAFIQ,MUHAMMADZIA-UR-REHMAN,MUHAMMADULLAH KHAN,ISLAMNADEEM ARSHAD,MUHAMMADAHMED KHAN,SIRAJ 2,1-Benzothiazine 2,2-dioxides Schiff bases Anti-bacterial activity Methyl anthranilate A convenient ultrasound assisted synthesis of new anti-bacterial N-benzylidene-N'-(1-methyl-2, 2-dioxo-2,3-dihydro-1H-2λ6-benzo[c][1,2]thiazin-4-ylidene)-hydrazines from methyl anthranilate is reported. Methyl anthranilate was reacted with methane sulfonyl chloride, followed by N-alkylation and subsequent base catalyzed cyclization. Hydrazinolysis of the cyclized products followed by their ultrasound mediated condensations with different benzaldehydes yielded the title compounds. Some of these compounds showed good anti-bacterial activity against Pseudomonas aeruginosa, Salmonella typhimurium and Staphylococcus aureus.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100001en10.4067/S0717-97072011000100001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	2,1-Benzothiazine 2,2-dioxides Schiff bases Anti-bacterial activity Methyl anthranilate
spellingShingle	2,1-Benzothiazine 2,2-dioxides Schiff bases Anti-bacterial activity Methyl anthranilate SHAFIQ,MUHAMMAD ZIA-UR-REHMAN,MUHAMMAD ULLAH KHAN,ISLAM NADEEM ARSHAD,MUHAMMAD AHMED KHAN,SIRAJ SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE
description	A convenient ultrasound assisted synthesis of new anti-bacterial N-benzylidene-N'-(1-methyl-2, 2-dioxo-2,3-dihydro-1H-2λ6-benzo[c][1,2]thiazin-4-ylidene)-hydrazines from methyl anthranilate is reported. Methyl anthranilate was reacted with methane sulfonyl chloride, followed by N-alkylation and subsequent base catalyzed cyclization. Hydrazinolysis of the cyclized products followed by their ultrasound mediated condensations with different benzaldehydes yielded the title compounds. Some of these compounds showed good anti-bacterial activity against Pseudomonas aeruginosa, Salmonella typhimurium and Staphylococcus aureus.
author	SHAFIQ,MUHAMMAD ZIA-UR-REHMAN,MUHAMMAD ULLAH KHAN,ISLAM NADEEM ARSHAD,MUHAMMAD AHMED KHAN,SIRAJ
author_facet	SHAFIQ,MUHAMMAD ZIA-UR-REHMAN,MUHAMMAD ULLAH KHAN,ISLAM NADEEM ARSHAD,MUHAMMAD AHMED KHAN,SIRAJ
author_sort	SHAFIQ,MUHAMMAD
title	SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE
title_short	SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE
title_full	SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE
title_fullStr	SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE
title_full_unstemmed	SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE
title_sort	synthesis of novel anti-bacterial 2,1-benzothiazine 2,2-dioxides derived from methyl anthranilate
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100001
work_keys_str_mv	AT shafiqmuhammad synthesisofnovelantibacterial21benzothiazine22dioxidesderivedfrommethylanthranilate AT ziaurrehmanmuhammad synthesisofnovelantibacterial21benzothiazine22dioxidesderivedfrommethylanthranilate AT ullahkhanislam synthesisofnovelantibacterial21benzothiazine22dioxidesderivedfrommethylanthranilate AT nadeemarshadmuhammad synthesisofnovelantibacterial21benzothiazine22dioxidesderivedfrommethylanthranilate AT ahmedkhansiraj synthesisofnovelantibacterial21benzothiazine22dioxidesderivedfrommethylanthranilate
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SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE

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