SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS

Simple, rapid, accurate, precise and sensitive spectrophotometric method for the microdetermination of enalapril maleate (ENM) and lisinopril dihydrate (LIS) has been developed. The method is based on oxidation of the drug by potassium permanganate in acidic medium and determine the unreacted oxidan...

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Autores principales:	SHAMA,SAYED A, AMIN,ALAA S, OMARA,HANY
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	spectrophotometric enalapril maleate lisinopril dihydrate redox reaction pharmaceutical analysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100009
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spelling	oai:scielo:S0717-970720110001000092011-06-17SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONSSHAMA,SAYED AAMIN,ALAA SOMARA,HANY spectrophotometric enalapril maleate lisinopril dihydrate redox reaction pharmaceutical analysis Simple, rapid, accurate, precise and sensitive spectrophotometric method for the microdetermination of enalapril maleate (ENM) and lisinopril dihydrate (LIS) has been developed. The method is based on oxidation of the drug by potassium permanganate in acidic medium and determine the unreacted oxidant by measuring the decrease in absorbance for three different acidic dyes; acid red 73 (AR), amaranth dye [acid red 27] (AM) and acid orange 7 (AO) at a suitable λmax (510, 521 and 484 nm for ENM and 509, 521 and 485 nm for LIS), respectively. Regression analysis of Beer's law plots showed good correlation in the concentration ranges 0.7-12, 0.5-7.6 and 0.6-9.5 µg mL-1 and 0.5-9.0, 0.4-6.1 and 0.4-7.2 µg mL-1 for ENM and LIS using AR, AM and AO, respectively. The apparent molar absorptivity, Sandell sensitivity, detection and quantitation limits are calculated. Statistical treatment of the results reflects that the proposed procedures are precise, accurate and easily applicable for the determination of ENM and LIS in pure and in pharmaceutical preparations.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100009en10.4067/S0717-97072011000100009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	spectrophotometric enalapril maleate lisinopril dihydrate redox reaction pharmaceutical analysis
spellingShingle	spectrophotometric enalapril maleate lisinopril dihydrate redox reaction pharmaceutical analysis SHAMA,SAYED A AMIN,ALAA S OMARA,HANY SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS
description	Simple, rapid, accurate, precise and sensitive spectrophotometric method for the microdetermination of enalapril maleate (ENM) and lisinopril dihydrate (LIS) has been developed. The method is based on oxidation of the drug by potassium permanganate in acidic medium and determine the unreacted oxidant by measuring the decrease in absorbance for three different acidic dyes; acid red 73 (AR), amaranth dye [acid red 27] (AM) and acid orange 7 (AO) at a suitable λmax (510, 521 and 484 nm for ENM and 509, 521 and 485 nm for LIS), respectively. Regression analysis of Beer's law plots showed good correlation in the concentration ranges 0.7-12, 0.5-7.6 and 0.6-9.5 µg mL-1 and 0.5-9.0, 0.4-6.1 and 0.4-7.2 µg mL-1 for ENM and LIS using AR, AM and AO, respectively. The apparent molar absorptivity, Sandell sensitivity, detection and quantitation limits are calculated. Statistical treatment of the results reflects that the proposed procedures are precise, accurate and easily applicable for the determination of ENM and LIS in pure and in pharmaceutical preparations.
author	SHAMA,SAYED A AMIN,ALAA S OMARA,HANY
author_facet	SHAMA,SAYED A AMIN,ALAA S OMARA,HANY
author_sort	SHAMA,SAYED A
title	SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS
title_short	SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS
title_full	SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS
title_fullStr	SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS
title_full_unstemmed	SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS
title_sort	spectrophotometry microdetermination of some antihypertensive drugs in pure form and in pharmaceutical formulations
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100009
work_keys_str_mv	AT shamasayeda spectrophotometrymicrodeterminationofsomeantihypertensivedrugsinpureformandinpharmaceuticalformulations AT aminalaas spectrophotometrymicrodeterminationofsomeantihypertensivedrugsinpureformandinpharmaceuticalformulations AT omarahany spectrophotometrymicrodeterminationofsomeantihypertensivedrugsinpureformandinpharmaceuticalformulations
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SPECTROPHOTOMETRY MICRODETERMINATION OF SOME ANTIHYPERTENSIVE DRUGS IN PURE FORM AND IN PHARMACEUTICAL FORMULATIONS

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