FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES

FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES

The interaction between Florfenicol (FF), Hydroxypropyl-β-cyclodextrin (HPβCD), and Chitosan (CH) has been studied in aqueous solution and in solid state, using 3 preparation methods (Evaporation, Lyophilization, Spray Drying) for HPβCD and only Spray Drying for Chitosan....

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Autores principales: ROGEL,CRISTIAN, MENDOZA,NÉSTOR, TRONCOSO,JOSÉ, GONZÁLEZ,JAVIER, VON PLESSING,CARLOS
Lenguaje:English
Publicado: Sociedad Chilena de Química 2011
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100011
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spelling oai:scielo:S0717-970720110001000112011-06-17FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLESROGEL,CRISTIANMENDOZA,NÉSTORTRONCOSO,JOSÉGONZÁLEZ,JAVIERVON PLESSING,CARLOSThe interaction between Florfenicol (FF), Hydroxypropyl-β-cyclodextrin (HPβCD), and Chitosan (CH) has been studied in aqueous solution and in solid state, using 3 preparation methods (Evaporation, Lyophilization, Spray Drying) for HPβCD and only Spray Drying for Chitosan. The phase solubility study shows that the complex is formed with 1:1 stoichiometry and 181,4 M¹ as the association constant. The analysis with Differential Scanning Calorimetry (DSC) together with Scanning Electron Microscopy (SEM) micrographs evidenced the formation of inclusion complexes, mainly with the product prepared by spray drying. Studies in vitro showed that FF solubility was improved almost to double, with a better dissolution profile exhibited by the product prepared by spray drying.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100011en10.4067/S0717-97072011000100011
institution Scielo Chile
collection Scielo Chile
language English
description The interaction between Florfenicol (FF), Hydroxypropyl-β-cyclodextrin (HPβCD), and Chitosan (CH) has been studied in aqueous solution and in solid state, using 3 preparation methods (Evaporation, Lyophilization, Spray Drying) for HPβCD and only Spray Drying for Chitosan. The phase solubility study shows that the complex is formed with 1:1 stoichiometry and 181,4 M¹ as the association constant. The analysis with Differential Scanning Calorimetry (DSC) together with Scanning Electron Microscopy (SEM) micrographs evidenced the formation of inclusion complexes, mainly with the product prepared by spray drying. Studies in vitro showed that FF solubility was improved almost to double, with a better dissolution profile exhibited by the product prepared by spray drying.
author ROGEL,CRISTIAN
MENDOZA,NÉSTOR
TRONCOSO,JOSÉ
GONZÁLEZ,JAVIER
VON PLESSING,CARLOS
spellingShingle ROGEL,CRISTIAN
MENDOZA,NÉSTOR
TRONCOSO,JOSÉ
GONZÁLEZ,JAVIER
VON PLESSING,CARLOS
FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES
author_facet ROGEL,CRISTIAN
MENDOZA,NÉSTOR
TRONCOSO,JOSÉ
GONZÁLEZ,JAVIER
VON PLESSING,CARLOS
author_sort ROGEL,CRISTIAN
title FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES
title_short FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES
title_full FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES
title_fullStr FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES
title_full_unstemmed FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES
title_sort formulation and characterization of inclusion complexes using hydroxypropyl-β-cyclodextrin and florfenicol with chitosan microparticles
publisher Sociedad Chilena de Química
publishDate 2011
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000100011
work_keys_str_mv AT rogelcristian formulationandcharacterizationofinclusioncomplexesusinghydroxypropyl946cyclodextrinandflorfenicolwithchitosanmicroparticles
AT mendozanestor formulationandcharacterizationofinclusioncomplexesusinghydroxypropyl946cyclodextrinandflorfenicolwithchitosanmicroparticles
AT troncosojose formulationandcharacterizationofinclusioncomplexesusinghydroxypropyl946cyclodextrinandflorfenicolwithchitosanmicroparticles
AT gonzalezjavier formulationandcharacterizationofinclusioncomplexesusinghydroxypropyl946cyclodextrinandflorfenicolwithchitosanmicroparticles
AT vonplessingcarlos formulationandcharacterizationofinclusioncomplexesusinghydroxypropyl946cyclodextrinandflorfenicolwithchitosanmicroparticles
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