ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS

The distribution behavior of ofloaxcin (OFLX) enantiomers in a two-phase system was examined using a new mixed complex chiral selector consisting of di(2-ethylhexyl) phosphoric acid (D2EHPA) and two tartaric acid derivatives with n-octanol as diluents. The influence of composition of mixed complex c...

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Autores principales:	TIAN,LINGXING, YANG,WEIJIE, CHEN,XIAOQING, XIE,YIXI
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	Enantioselective extraction ofloxacin enantiomers D2EHPA tartaric acid derivative complex chiral selectors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000200003
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spelling	oai:scielo:S0717-970720110002000032011-09-01ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORSTIAN,LINGXINGYANG,WEIJIECHEN,XIAOQINGXIE,YIXI Enantioselective extraction ofloxacin enantiomers D2EHPA tartaric acid derivative complex chiral selectors The distribution behavior of ofloaxcin (OFLX) enantiomers in a two-phase system was examined using a new mixed complex chiral selector consisting of di(2-ethylhexyl) phosphoric acid (D2EHPA) and two tartaric acid derivatives with n-octanol as diluents. The influence of composition of mixed complex chiral selector, initial concentration of OFLX, pH of aqueous phase and temperature was investigated. A maximum enantioselectivity of 2.43 was obtained when the molar concentration ratio of L-(-)-DBTA to L-(-)-DTTA is 2:3 L-(-)-DTTA concentration 0.18 mol/L, L-(-)-DBTA concentration 0.12mol/L) and the pH of aqueous phase is 6.86 at 25°C, with Dd and Dl up to a relative high value of 10.2 and 4.20, respectively. The results indicated a useful way of searching new efficient chiral selectors and it was proved also helpful to optimize the extraction systems and realize the large-scale production of the pure isomer of racemic mixtures with extraction methods.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.2 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000200003en10.4067/S0717-97072011000200003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Enantioselective extraction ofloxacin enantiomers D2EHPA tartaric acid derivative complex chiral selectors
spellingShingle	Enantioselective extraction ofloxacin enantiomers D2EHPA tartaric acid derivative complex chiral selectors TIAN,LINGXING YANG,WEIJIE CHEN,XIAOQING XIE,YIXI ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS
description	The distribution behavior of ofloaxcin (OFLX) enantiomers in a two-phase system was examined using a new mixed complex chiral selector consisting of di(2-ethylhexyl) phosphoric acid (D2EHPA) and two tartaric acid derivatives with n-octanol as diluents. The influence of composition of mixed complex chiral selector, initial concentration of OFLX, pH of aqueous phase and temperature was investigated. A maximum enantioselectivity of 2.43 was obtained when the molar concentration ratio of L-(-)-DBTA to L-(-)-DTTA is 2:3 L-(-)-DTTA concentration 0.18 mol/L, L-(-)-DBTA concentration 0.12mol/L) and the pH of aqueous phase is 6.86 at 25°C, with Dd and Dl up to a relative high value of 10.2 and 4.20, respectively. The results indicated a useful way of searching new efficient chiral selectors and it was proved also helpful to optimize the extraction systems and realize the large-scale production of the pure isomer of racemic mixtures with extraction methods.
author	TIAN,LINGXING YANG,WEIJIE CHEN,XIAOQING XIE,YIXI
author_facet	TIAN,LINGXING YANG,WEIJIE CHEN,XIAOQING XIE,YIXI
author_sort	TIAN,LINGXING
title	ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS
title_short	ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS
title_full	ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS
title_fullStr	ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS
title_full_unstemmed	ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS
title_sort	enantioselective extraction of racemic ofloxacin by di(2-ethylhexyl)phosphoric acid and tartaric acid derivatives as mixed complex chiral selectors
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000200003
work_keys_str_mv	AT tianlingxing enantioselectiveextractionofracemicofloxacinbydi2ethylhexylphosphoricacidandtartaricacidderivativesasmixedcomplexchiralselectors AT yangweijie enantioselectiveextractionofracemicofloxacinbydi2ethylhexylphosphoricacidandtartaricacidderivativesasmixedcomplexchiralselectors AT chenxiaoqing enantioselectiveextractionofracemicofloxacinbydi2ethylhexylphosphoricacidandtartaricacidderivativesasmixedcomplexchiralselectors AT xieyixi enantioselectiveextractionofracemicofloxacinbydi2ethylhexylphosphoricacidandtartaricacidderivativesasmixedcomplexchiralselectors
_version_	1718445444960354304

ENANTIOSELECTIVE EXTRACTION OF RACEMIC OFLOXACIN BY DI(2-ETHYLHEXYL)PHOSPHORIC ACID AND TARTARIC ACID DERIVATIVES AS MIXED COMPLEX CHIRAL SELECTORS

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