SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES

Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyri...

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Autores principales:	HUSAIN,ASIF, AHMAD,AFTAB, BHANDARI,ANIL, RAM,VEERMA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	Pyridazinone antitubercular mycobacteria furanone
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000300013
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spelling	oai:scielo:S0717-970720110003000132012-01-11SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVESHUSAIN,ASIFAHMAD,AFTABBHANDARI,ANILRAM,VEERMA Pyridazinone antitubercular mycobacteria furanone Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity. Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.3 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000300013en10.4067/S0717-97072011000300013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Pyridazinone antitubercular mycobacteria furanone
spellingShingle	Pyridazinone antitubercular mycobacteria furanone HUSAIN,ASIF AHMAD,AFTAB BHANDARI,ANIL RAM,VEERMA SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES
description	Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity. Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.
author	HUSAIN,ASIF AHMAD,AFTAB BHANDARI,ANIL RAM,VEERMA
author_facet	HUSAIN,ASIF AHMAD,AFTAB BHANDARI,ANIL RAM,VEERMA
author_sort	HUSAIN,ASIF
title	SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES
title_short	SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES
title_full	SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES
title_fullStr	SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES
title_full_unstemmed	SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES
title_sort	synthesis and antitubercular activity of pyridazinone derivatives
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000300013
work_keys_str_mv	AT husainasif synthesisandantitubercularactivityofpyridazinonederivatives AT ahmadaftab synthesisandantitubercularactivityofpyridazinonederivatives AT bhandarianil synthesisandantitubercularactivityofpyridazinonederivatives AT ramveerma synthesisandantitubercularactivityofpyridazinonederivatives
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SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF PYRIDAZINONE DERIVATIVES

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