SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES

SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES

Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activit...

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Autores principales: MISHRA,RAVINESH, SIDDIQUI,ANEES A, HUSAIN,ASIF, RASHID,MOHD, PRAKASH,ATISH, TAILANG,MUKUL, KUMAR,MUNEESH, SRIVASTAVA,NEETI
Lenguaje:English
Publicado: Sociedad Chilena de Química 2011
Materias:
Pyridazine
Antihypertensive activity
Non invasive tail-cuff method
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400006
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spelling oai:scielo:S0717-970720110004000062012-03-06SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVESMISHRA,RAVINESHSIDDIQUI,ANEES AHUSAIN,ASIFRASHID,MOHDPRAKASH,ATISHTAILANG,MUKULKUMAR,MUNEESHSRIVASTAVA,NEETI Pyridazine Antihypertensive activity Non invasive tail-cuff method Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e and 4i showed appreciable antihypertensive activity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400006en10.4067/S0717-97072011000400006
institution Scielo Chile
collection Scielo Chile
language English
topic Pyridazine
Antihypertensive activity
Non invasive tail-cuff method
spellingShingle Pyridazine
Antihypertensive activity
Non invasive tail-cuff method
MISHRA,RAVINESH
SIDDIQUI,ANEES A
HUSAIN,ASIF
RASHID,MOHD
PRAKASH,ATISH
TAILANG,MUKUL
KUMAR,MUNEESH
SRIVASTAVA,NEETI
SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES
description Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e and 4i showed appreciable antihypertensive activity.
author MISHRA,RAVINESH
SIDDIQUI,ANEES A
HUSAIN,ASIF
RASHID,MOHD
PRAKASH,ATISH
TAILANG,MUKUL
KUMAR,MUNEESH
SRIVASTAVA,NEETI
author_facet MISHRA,RAVINESH
SIDDIQUI,ANEES A
HUSAIN,ASIF
RASHID,MOHD
PRAKASH,ATISH
TAILANG,MUKUL
KUMAR,MUNEESH
SRIVASTAVA,NEETI
author_sort MISHRA,RAVINESH
title SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES
title_short SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES
title_full SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES
title_fullStr SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES
title_full_unstemmed SYNTHESIS, CHARACTERIZATION AND ANTIHYPERTENSIVE ACTIVITY OF SOME NEW SUBSTITUTED PYRIDAZINE DERIVATIVES
title_sort synthesis, characterization and antihypertensive activity of some new substituted pyridazine derivatives
publisher Sociedad Chilena de Química
publishDate 2011
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400006
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