SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY

SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY

The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through a five steps sequence to provide indole amides 6(a-f) in 75-92% yield...

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Autores principales: PESSOA-MAHANA,HERNÁN, CUEVAS M,IGNACIO, PESSOA-MAHANA,C. DAVID, ARAYA-MATURANA,RAMIRO, ALMODOVAR FAJARDO,IRIUX, SAITZ BARRÍA,CLAUDIO
Lenguaje:English
Publicado: Sociedad Chilena de Química 2011
Materias:
Indole
Arylpiperazines
dopaminergic activity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400009
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spelling oai:scielo:S0717-970720110004000092012-03-06SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITYPESSOA-MAHANA,HERNÁNCUEVAS M,IGNACIOPESSOA-MAHANA,C. DAVIDARAYA-MATURANA,RAMIROALMODOVAR FAJARDO,IRIUXSAITZ BARRÍA,CLAUDIO Indole Arylpiperazines dopaminergic activity The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through a five steps sequence to provide indole amides 6(a-f) in 75-92% yield.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400009en10.4067/S0717-97072011000400009
institution Scielo Chile
collection Scielo Chile
language English
topic Indole
Arylpiperazines
dopaminergic activity
spellingShingle Indole
Arylpiperazines
dopaminergic activity
PESSOA-MAHANA,HERNÁN
CUEVAS M,IGNACIO
PESSOA-MAHANA,C. DAVID
ARAYA-MATURANA,RAMIRO
ALMODOVAR FAJARDO,IRIUX
SAITZ BARRÍA,CLAUDIO
SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
description The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through a five steps sequence to provide indole amides 6(a-f) in 75-92% yield.
author PESSOA-MAHANA,HERNÁN
CUEVAS M,IGNACIO
PESSOA-MAHANA,C. DAVID
ARAYA-MATURANA,RAMIRO
ALMODOVAR FAJARDO,IRIUX
SAITZ BARRÍA,CLAUDIO
author_facet PESSOA-MAHANA,HERNÁN
CUEVAS M,IGNACIO
PESSOA-MAHANA,C. DAVID
ARAYA-MATURANA,RAMIRO
ALMODOVAR FAJARDO,IRIUX
SAITZ BARRÍA,CLAUDIO
author_sort PESSOA-MAHANA,HERNÁN
title SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
title_short SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
title_full SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
title_fullStr SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
title_full_unstemmed SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES: NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
title_sort synthesis of 1-benzyl-3-[4-(aryl-1-piperazinyl) carbonyl]-1h-indoles: novel ligands with potential d4 dopaminergic activity
publisher Sociedad Chilena de Química
publishDate 2011
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400009
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