SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES

A series of transition metal complexes of Fe(III), Co(II) and Cu(II) containing the bidentate N,O and N,S donor ligand, camphor semicarbazone (1,7,7-trimethylbicyclo [2,2,1]heptanesemicarbazone, TBHSC) and camphor thiosemicarbazone (1,7,7- trimethylbicyclo [2,2,1]heptanethiosemicarbazone, TBHTSC) ha...

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Autores principales:	CHOUDHARY,ALKA, SHARMA,RENU, NAGAR,MEENA, MOHSIN,MOHAMMED, MEENA,HAR SAHAY
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	molar conductance thermogravimetric analysis radical scavenging activity DPPH
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400019
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spelling	oai:scielo:S0717-970720110004000192012-03-06SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVESCHOUDHARY,ALKASHARMA,RENUNAGAR,MEENAMOHSIN,MOHAMMEDMEENA,HAR SAHAY molar conductance thermogravimetric analysis radical scavenging activity DPPH A series of transition metal complexes of Fe(III), Co(II) and Cu(II) containing the bidentate N,O and N,S donor ligand, camphor semicarbazone (1,7,7-trimethylbicyclo [2,2,1]heptanesemicarbazone, TBHSC) and camphor thiosemicarbazone (1,7,7- trimethylbicyclo [2,2,1]heptanethiosemicarbazone, TBHTSC) have been synthesized and characterized by elemental analysis, molar conductance measurement and various spectral studies (IR, electronic and FAB Mass) and thermogravimetric analysis (TGA). All the metal complexes (1-8) are [M(LH)Cl2] and [M(LH)2Cl2] type, where M = Fe(III), Co(II) and Cu(II); LH = TBHSC and TBHTSC. TBHSC and TBHTSC act as neutral bidentate ligands in all the complexes. FAB mass spectroscopic studies of the three representative complexes (1), (2), (4), (5) and (8) suggest their monomeric nature. The proposed geometries of the complexes were octahedral geometry for 1:2 complexes, square planar for 1:1 complexes and distorted octahedral for Cu(II) complexes (1:2). The free radical scavenging activity of newly synthesized ligands (TBHSC, TBHTSC) and their metal complexes have been determined at the concentration range of 50-1000 μg/ml by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). All the compounds have shown encouraging antioxidant activities. The least IC50 value (111.0 μg/ml) for compound (5) showed the potent scavenging property compared to other test compounds.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400019en10.4067/S0717-97072011000400019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	molar conductance thermogravimetric analysis radical scavenging activity DPPH
spellingShingle	molar conductance thermogravimetric analysis radical scavenging activity DPPH CHOUDHARY,ALKA SHARMA,RENU NAGAR,MEENA MOHSIN,MOHAMMED MEENA,HAR SAHAY SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES
description	A series of transition metal complexes of Fe(III), Co(II) and Cu(II) containing the bidentate N,O and N,S donor ligand, camphor semicarbazone (1,7,7-trimethylbicyclo [2,2,1]heptanesemicarbazone, TBHSC) and camphor thiosemicarbazone (1,7,7- trimethylbicyclo [2,2,1]heptanethiosemicarbazone, TBHTSC) have been synthesized and characterized by elemental analysis, molar conductance measurement and various spectral studies (IR, electronic and FAB Mass) and thermogravimetric analysis (TGA). All the metal complexes (1-8) are [M(LH)Cl2] and [M(LH)2Cl2] type, where M = Fe(III), Co(II) and Cu(II); LH = TBHSC and TBHTSC. TBHSC and TBHTSC act as neutral bidentate ligands in all the complexes. FAB mass spectroscopic studies of the three representative complexes (1), (2), (4), (5) and (8) suggest their monomeric nature. The proposed geometries of the complexes were octahedral geometry for 1:2 complexes, square planar for 1:1 complexes and distorted octahedral for Cu(II) complexes (1:2). The free radical scavenging activity of newly synthesized ligands (TBHSC, TBHTSC) and their metal complexes have been determined at the concentration range of 50-1000 μg/ml by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). All the compounds have shown encouraging antioxidant activities. The least IC50 value (111.0 μg/ml) for compound (5) showed the potent scavenging property compared to other test compounds.
author	CHOUDHARY,ALKA SHARMA,RENU NAGAR,MEENA MOHSIN,MOHAMMED MEENA,HAR SAHAY
author_facet	CHOUDHARY,ALKA SHARMA,RENU NAGAR,MEENA MOHSIN,MOHAMMED MEENA,HAR SAHAY
author_sort	CHOUDHARY,ALKA
title	SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES
title_short	SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES
title_full	SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES
title_fullStr	SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES
title_full_unstemmed	SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES
title_sort	synthesis, characterization and antioxidant activity of some transition metal complexes with terpenoid derivatives
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400019
work_keys_str_mv	AT choudharyalka synthesischaracterizationandantioxidantactivityofsometransitionmetalcomplexeswithterpenoidderivatives AT sharmarenu synthesischaracterizationandantioxidantactivityofsometransitionmetalcomplexeswithterpenoidderivatives AT nagarmeena synthesischaracterizationandantioxidantactivityofsometransitionmetalcomplexeswithterpenoidderivatives AT mohsinmohammed synthesischaracterizationandantioxidantactivityofsometransitionmetalcomplexeswithterpenoidderivatives AT meenaharsahay synthesischaracterizationandantioxidantactivityofsometransitionmetalcomplexeswithterpenoidderivatives
_version_	1718445456406609920

SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF SOME TRANSITION METAL COMPLEXES WITH TERPENOID DERIVATIVES

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