EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES

Three simple and sensitive extractive spectrophotometric methods have been described for the assay of Rasagiline mesylate either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	CHENNAIAH,M, VEERAIAH,T, CHARAN SINGH,T, VENKATESHWARLU,G
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	Rasagiline mesylate Bromothymol blue Bromophenol blue Bromocresol green Spectrophotometry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400022
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072011000400022
record_format	dspace
spelling	oai:scielo:S0717-970720110004000222012-03-06EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYESCHENNAIAH,MVEERAIAH,TCHARAN SINGH,TVENKATESHWARLU,G Rasagiline mesylate Bromothymol blue Bromophenol blue Bromocresol green Spectrophotometry Three simple and sensitive extractive spectrophotometric methods have been described for the assay of Rasagiline mesylate either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extracted complexes showed absorbance maxima at 414 nm for all three methods. Beer's law is obeyed in the concentration ranges 3.0-30, 3.0.0-30 and 2.0-25µg/ml with BTB, BPB and BCG respectively. The effect of concentration of dye, pH, and interference of excipients have been studied and optimized. The limits of detection and quantification have been determined for three methods. All the three methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial tablets and results of analysis were validated statistically through recovery studies.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400022en10.4067/S0717-97072011000400022
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Rasagiline mesylate Bromothymol blue Bromophenol blue Bromocresol green Spectrophotometry
spellingShingle	Rasagiline mesylate Bromothymol blue Bromophenol blue Bromocresol green Spectrophotometry CHENNAIAH,M VEERAIAH,T CHARAN SINGH,T VENKATESHWARLU,G EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES
description	Three simple and sensitive extractive spectrophotometric methods have been described for the assay of Rasagiline mesylate either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extracted complexes showed absorbance maxima at 414 nm for all three methods. Beer's law is obeyed in the concentration ranges 3.0-30, 3.0.0-30 and 2.0-25µg/ml with BTB, BPB and BCG respectively. The effect of concentration of dye, pH, and interference of excipients have been studied and optimized. The limits of detection and quantification have been determined for three methods. All the three methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial tablets and results of analysis were validated statistically through recovery studies.
author	CHENNAIAH,M VEERAIAH,T CHARAN SINGH,T VENKATESHWARLU,G
author_facet	CHENNAIAH,M VEERAIAH,T CHARAN SINGH,T VENKATESHWARLU,G
author_sort	CHENNAIAH,M
title	EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES
title_short	EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES
title_full	EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES
title_fullStr	EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES
title_full_unstemmed	EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES
title_sort	extractive spectrophotometry methods for determination of rasagiline mesylate in pharmaceutical formulations using acidic triphenylmethane dyes
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400022
work_keys_str_mv	AT chennaiahm extractivespectrophotometrymethodsfordeterminationofrasagilinemesylateinpharmaceuticalformulationsusingacidictriphenylmethanedyes AT veeraiaht extractivespectrophotometrymethodsfordeterminationofrasagilinemesylateinpharmaceuticalformulationsusingacidictriphenylmethanedyes AT charansinght extractivespectrophotometrymethodsfordeterminationofrasagilinemesylateinpharmaceuticalformulationsusingacidictriphenylmethanedyes AT venkateshwarlug extractivespectrophotometrymethodsfordeterminationofrasagilinemesylateinpharmaceuticalformulationsusingacidictriphenylmethanedyes
_version_	1718445456916217856

EXTRACTIVE SPECTROPHOTOMETRY METHODS FOR DETERMINATION OF RASAGILINE MESYLATE IN PHARMACEUTICAL FORMULATIONS USING ACIDIC TRIPHENYLMETHANE DYES

Ejemplares similares