ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES

The lipoxygenases (LOX) are a family of non-heme iron-containing dioxygenases which catalyze the stereospecific insertion of molecular oxygen into arachidonic acid, leading to hydroxy derivatives as end products. In this work, we studied the behavior of seven isoflavans on 15-soybean lipoxygenases (...

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Autores principales:	MASCAYANO,CAROLINA, CAROLI REZENDE,MARCOS, RIVERA,YENIFER, ESPINOSA,VICTORIA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	Soybean Lipoxygenase Isoflavans Inhibitors IC50 Values Docking
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400024
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spelling	oai:scielo:S0717-970720110004000242012-03-06ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIESMASCAYANO,CAROLINACAROLI REZENDE,MARCOSRIVERA,YENIFERESPINOSA,VICTORIA Soybean Lipoxygenase Isoflavans Inhibitors IC50 Values Docking The lipoxygenases (LOX) are a family of non-heme iron-containing dioxygenases which catalyze the stereospecific insertion of molecular oxygen into arachidonic acid, leading to hydroxy derivatives as end products. In this work, we studied the behavior of seven isoflavans on 15-soybean lipoxygenases (15-sLOX), comparing them with the known inhibitors quercetin and 3, 4-dihydroxybenzoic acid. Four of the seven investigated isoflavans showed IC50 values smaller than 50 µM , being more potent than quercetin or 3, 4-dihydroxybenzoic acid. Besides a catecholic pattern, the presence of an aromatic ring B seems to confer additional activity to these compounds, a result which was rationalized by docking studies of these isoflavanss into the enzyme binding site.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400024en10.4067/S0717-97072011000400024
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Soybean Lipoxygenase Isoflavans Inhibitors IC50 Values Docking
spellingShingle	Soybean Lipoxygenase Isoflavans Inhibitors IC50 Values Docking MASCAYANO,CAROLINA CAROLI REZENDE,MARCOS RIVERA,YENIFER ESPINOSA,VICTORIA ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES
description	The lipoxygenases (LOX) are a family of non-heme iron-containing dioxygenases which catalyze the stereospecific insertion of molecular oxygen into arachidonic acid, leading to hydroxy derivatives as end products. In this work, we studied the behavior of seven isoflavans on 15-soybean lipoxygenases (15-sLOX), comparing them with the known inhibitors quercetin and 3, 4-dihydroxybenzoic acid. Four of the seven investigated isoflavans showed IC50 values smaller than 50 µM , being more potent than quercetin or 3, 4-dihydroxybenzoic acid. Besides a catecholic pattern, the presence of an aromatic ring B seems to confer additional activity to these compounds, a result which was rationalized by docking studies of these isoflavanss into the enzyme binding site.
author	MASCAYANO,CAROLINA CAROLI REZENDE,MARCOS RIVERA,YENIFER ESPINOSA,VICTORIA
author_facet	MASCAYANO,CAROLINA CAROLI REZENDE,MARCOS RIVERA,YENIFER ESPINOSA,VICTORIA
author_sort	MASCAYANO,CAROLINA
title	ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES
title_short	ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES
title_full	ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES
title_fullStr	ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES
title_full_unstemmed	ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES
title_sort	isoflavans derivatives as inhibitors of soybean lipoxygenase: in-vitro and docking studies
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400024
work_keys_str_mv	AT mascayanocarolina isoflavansderivativesasinhibitorsofsoybeanlipoxygenaseinvitroanddockingstudies AT carolirezendemarcos isoflavansderivativesasinhibitorsofsoybeanlipoxygenaseinvitroanddockingstudies AT riverayenifer isoflavansderivativesasinhibitorsofsoybeanlipoxygenaseinvitroanddockingstudies AT espinosavictoria isoflavansderivativesasinhibitorsofsoybeanlipoxygenaseinvitroanddockingstudies
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ISOFLAVANS DERIVATIVES AS INHIBITORS OF SOYBEAN LIPOXYGENASE: IN-VITRO AND DOCKING STUDIES

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