PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX

The objective of this study was to prepare an inclusion complex of the insecticide emamectin benzoate (EB) with hydroxypropyl-β-cyclodextrin (HO-β-CD) by co-evaporation and spray drying methods. The complexation of both compounds was evaluated on the aqueous and solid state using p...

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Autores principales:	TORRES,PABLO, VILLA,FRANCISCO, GONZÁLEZ,JAVIER, TRONCOSO,JOSÉ, VONPLESSING,CARLOS
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2011
Materias:	Emamectin benzoate cyclodextrin inclusion complex salmon
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400029
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spelling	oai:scielo:S0717-970720110004000292012-03-06PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEXTORRES,PABLOVILLA,FRANCISCOGONZÁLEZ,JAVIERTRONCOSO,JOSÉVONPLESSING,CARLOS Emamectin benzoate cyclodextrin inclusion complex salmon The objective of this study was to prepare an inclusion complex of the insecticide emamectin benzoate (EB) with hydroxypropyl-β-cyclodextrin (HO-β-CD) by co-evaporation and spray drying methods. The complexation of both compounds was evaluated on the aqueous and solid state using phase solubility diagrams, differential scanning calorimetry (DSC), X-Ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The aqueous solubility of the inclusion complexes at pH 8 had a 2-fold increase respect to the drug alone and dissolution profiles showed a rise in the dissolution rate. These results suggest that the use of HO-β-CD could be an interesting alternative to enhance the bioavailability of EB in salmons.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.56 n.4 20112011-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400029en10.4067/S0717-97072011000400029
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Emamectin benzoate cyclodextrin inclusion complex salmon
spellingShingle	Emamectin benzoate cyclodextrin inclusion complex salmon TORRES,PABLO VILLA,FRANCISCO GONZÁLEZ,JAVIER TRONCOSO,JOSÉ VONPLESSING,CARLOS PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX
description	The objective of this study was to prepare an inclusion complex of the insecticide emamectin benzoate (EB) with hydroxypropyl-β-cyclodextrin (HO-β-CD) by co-evaporation and spray drying methods. The complexation of both compounds was evaluated on the aqueous and solid state using phase solubility diagrams, differential scanning calorimetry (DSC), X-Ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The aqueous solubility of the inclusion complexes at pH 8 had a 2-fold increase respect to the drug alone and dissolution profiles showed a rise in the dissolution rate. These results suggest that the use of HO-β-CD could be an interesting alternative to enhance the bioavailability of EB in salmons.
author	TORRES,PABLO VILLA,FRANCISCO GONZÁLEZ,JAVIER TRONCOSO,JOSÉ VONPLESSING,CARLOS
author_facet	TORRES,PABLO VILLA,FRANCISCO GONZÁLEZ,JAVIER TRONCOSO,JOSÉ VONPLESSING,CARLOS
author_sort	TORRES,PABLO
title	PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX
title_short	PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX
title_full	PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX
title_fullStr	PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX
title_full_unstemmed	PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX
title_sort	preparation and characterization of the emamectin benzoate/hydroxypropyl-b-cyclodextrin inclusion complex
publisher	Sociedad Chilena de Química
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072011000400029
work_keys_str_mv	AT torrespablo preparationandcharacterizationoftheemamectinbenzoatehydroxypropylbcyclodextrininclusioncomplex AT villafrancisco preparationandcharacterizationoftheemamectinbenzoatehydroxypropylbcyclodextrininclusioncomplex AT gonzalezjavier preparationandcharacterizationoftheemamectinbenzoatehydroxypropylbcyclodextrininclusioncomplex AT troncosojose preparationandcharacterizationoftheemamectinbenzoatehydroxypropylbcyclodextrininclusioncomplex AT vonplessingcarlos preparationandcharacterizationoftheemamectinbenzoatehydroxypropylbcyclodextrininclusioncomplex
_version_	1718445458124177408

PREPARATION AND CHARACTERIZATION OF THE EMAMECTIN BENZOATE/HYDROXYPROPYL-B-CYCLODEXTRIN INCLUSION COMPLEX

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