4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

The synthesis of two new ligands 4,4'-(diphenylmethane-4,4'-diyldinitrilo)dipentan-2-one (H2L¹) and 4,4'-(diphenylether-4,4'-diyldinitrilo)dipentan-2-one (H2L²) is reported. The ligands have two acetylacetone subunits separated by diphenylmethane or diphenylether group. The ligan...

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Autores principales:	KARIPCIN,FATMA, ÖZMEN,ISMAIL, CULU,BURCIN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Schiff base copper(II) nickel(II) DNA cleavage extraction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100016
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spelling	oai:scielo:S0717-970720120001000162012-07-194,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIESKARIPCIN,FATMAÖZMEN,ISMAILCULU,BURCIN Schiff base copper(II) nickel(II) DNA cleavage extraction The synthesis of two new ligands 4,4'-(diphenylmethane-4,4'-diyldinitrilo)dipentan-2-one (H2L¹) and 4,4'-(diphenylether-4,4'-diyldinitrilo)dipentan-2-one (H2L²) is reported. The ligands have two acetylacetone subunits separated by diphenylmethane or diphenylether group. The ligands form stable dinuclear complexes with Ni(II) and Cu(II) ions. Ligands and their complexes were characterized by elemental analysis, m.p., IR, molar conductivity and magnetic moment measurements. The interaction between these compounds with DNA has also been investigated by agarose gel electrophoresis, we found that the nickel(II) and copper(II) complexes can cleave supercoiled pBR322 DNA to nicked and linear forms. The copper(II) complexes with H2O2 as a cooxidant exhibited the strongest cleaving activity. The free ligands were also characterized by ¹H NMR spectra. The IR of the free ligands and their complexes are compared and discussed. The extraction ability of the ligands have been examined by the liquid-liquid extraction of selected transition metal [Mn²+, Co²+, Ni²+, Cu²+, Zn²+, Cd²+, Hg²+ and Pb²+] cations. The ligands show strong binding ability toward mercury(II) ion.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100016en10.4067/S0717-97072012000100016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Schiff base copper(II) nickel(II) DNA cleavage extraction
spellingShingle	Schiff base copper(II) nickel(II) DNA cleavage extraction KARIPCIN,FATMA ÖZMEN,ISMAIL CULU,BURCIN 4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES
description	The synthesis of two new ligands 4,4'-(diphenylmethane-4,4'-diyldinitrilo)dipentan-2-one (H2L¹) and 4,4'-(diphenylether-4,4'-diyldinitrilo)dipentan-2-one (H2L²) is reported. The ligands have two acetylacetone subunits separated by diphenylmethane or diphenylether group. The ligands form stable dinuclear complexes with Ni(II) and Cu(II) ions. Ligands and their complexes were characterized by elemental analysis, m.p., IR, molar conductivity and magnetic moment measurements. The interaction between these compounds with DNA has also been investigated by agarose gel electrophoresis, we found that the nickel(II) and copper(II) complexes can cleave supercoiled pBR322 DNA to nicked and linear forms. The copper(II) complexes with H2O2 as a cooxidant exhibited the strongest cleaving activity. The free ligands were also characterized by ¹H NMR spectra. The IR of the free ligands and their complexes are compared and discussed. The extraction ability of the ligands have been examined by the liquid-liquid extraction of selected transition metal [Mn²+, Co²+, Ni²+, Cu²+, Zn²+, Cd²+, Hg²+ and Pb²+] cations. The ligands show strong binding ability toward mercury(II) ion.
author	KARIPCIN,FATMA ÖZMEN,ISMAIL CULU,BURCIN
author_facet	KARIPCIN,FATMA ÖZMEN,ISMAIL CULU,BURCIN
author_sort	KARIPCIN,FATMA
title	4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES
title_short	4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES
title_full	4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES
title_fullStr	4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES
title_full_unstemmed	4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES
title_sort	4,4'-(diphenylmethane-4,4'-diyldinitrilo)dipentan-2-one and 4,4'-(diphenylether-4,4'-diyldinitrilo)dipentan-2-one ligands and their ni(ii), cu(ii) complexes: synthesis, characterization, dna cleavage studies
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100016
work_keys_str_mv	AT karipcinfatma 44diphenylmethane44diyldinitrilodipentan2oneand44diphenylether44diyldinitrilodipentan2oneligandsandtheirniiicuiicomplexessynthesischaracterizationdnacleavagestudies AT ozmenismail 44diphenylmethane44diyldinitrilodipentan2oneand44diphenylether44diyldinitrilodipentan2oneligandsandtheirniiicuiicomplexessynthesischaracterizationdnacleavagestudies AT culuburcin 44diphenylmethane44diyldinitrilodipentan2oneand44diphenylether44diyldinitrilodipentan2oneligandsandtheirniiicuiicomplexessynthesischaracterizationdnacleavagestudies
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4,4'-(DIPHENYLMETHANE-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE AND 4,4'-(DIPHENYLETHER-4,4'-DIYLDINITRILO)DIPENTAN-2-ONE LIGANDS AND THEIR Ni(II), Cu(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE STUDIES

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