SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY

A simple, rapid and sensitive RP- HPTLC method has been established for the determination of Propranolol hydrochloride (PRH) and Flunarizine Dihydrochloride (FNZ) in bulk and capsule formulation. Separation of both these drugs were achieved on aluminum backed silica gel 60 RP-18 F254S HPTLC plates,...

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Autores principales:	PATIL,AMOD S, SHIRKHEDKAR,ATUL A, SURANA,SANJAY J, NAWALE,PRAJAKTA S
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Propranolol hydrochloride Flunarizine dihydrochloride RP- HPTLC
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100017
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spelling	oai:scielo:S0717-970720120001000172012-07-19SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRYPATIL,AMOD SSHIRKHEDKAR,ATUL ASURANA,SANJAY JNAWALE,PRAJAKTA S Propranolol hydrochloride Flunarizine dihydrochloride RP- HPTLC A simple, rapid and sensitive RP- HPTLC method has been established for the determination of Propranolol hydrochloride (PRH) and Flunarizine Dihydrochloride (FNZ) in bulk and capsule formulation. Separation of both these drugs were achieved on aluminum backed silica gel 60 RP-18 F254S HPTLC plates, prewashed with methanol using methanol: toluene: ammonia (7:3:0.5 v/v) as mobile phase. Densitometric scanning was performed at 267 nm. The Rf values for PRH and FNZ were found to be 0.63 and 0.48, respectively. The amount of PRH and FNZ estimated in capsule formulation were found to be 99.20 ± 1.04 and 98.89 ± 1.23, respectively. The accuracy of the method was found to be in the range of 99.30 - 100.41% for PRH and 99.56 -100.87 for FNZ. The method was validated as per ICH guidelines and can regularly used for analysis of PRH and FNZ in capsule dosage form.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100017en10.4067/S0717-97072012000100017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Propranolol hydrochloride Flunarizine dihydrochloride RP- HPTLC
spellingShingle	Propranolol hydrochloride Flunarizine dihydrochloride RP- HPTLC PATIL,AMOD S SHIRKHEDKAR,ATUL A SURANA,SANJAY J NAWALE,PRAJAKTA S SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY
description	A simple, rapid and sensitive RP- HPTLC method has been established for the determination of Propranolol hydrochloride (PRH) and Flunarizine Dihydrochloride (FNZ) in bulk and capsule formulation. Separation of both these drugs were achieved on aluminum backed silica gel 60 RP-18 F254S HPTLC plates, prewashed with methanol using methanol: toluene: ammonia (7:3:0.5 v/v) as mobile phase. Densitometric scanning was performed at 267 nm. The Rf values for PRH and FNZ were found to be 0.63 and 0.48, respectively. The amount of PRH and FNZ estimated in capsule formulation were found to be 99.20 ± 1.04 and 98.89 ± 1.23, respectively. The accuracy of the method was found to be in the range of 99.30 - 100.41% for PRH and 99.56 -100.87 for FNZ. The method was validated as per ICH guidelines and can regularly used for analysis of PRH and FNZ in capsule dosage form.
author	PATIL,AMOD S SHIRKHEDKAR,ATUL A SURANA,SANJAY J NAWALE,PRAJAKTA S
author_facet	PATIL,AMOD S SHIRKHEDKAR,ATUL A SURANA,SANJAY J NAWALE,PRAJAKTA S
author_sort	PATIL,AMOD S
title	SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY
title_short	SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY
title_full	SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY
title_fullStr	SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY
title_full_unstemmed	SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY
title_sort	simultaneous determination of propranolol hydrochloride and flunarizine dihydrochloride in bulk and capsule using reversed - phase high -performance thin layer chromatography / densitometry
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100017
work_keys_str_mv	AT patilamods simultaneousdeterminationofpropranololhydrochlorideandflunarizinedihydrochlorideinbulkandcapsuleusingreversedphasehighperformancethinlayerchromatographydensitometry AT shirkhedkaratula simultaneousdeterminationofpropranololhydrochlorideandflunarizinedihydrochlorideinbulkandcapsuleusingreversedphasehighperformancethinlayerchromatographydensitometry AT suranasanjayj simultaneousdeterminationofpropranololhydrochlorideandflunarizinedihydrochlorideinbulkandcapsuleusingreversedphasehighperformancethinlayerchromatographydensitometry AT nawaleprajaktas simultaneousdeterminationofpropranololhydrochlorideandflunarizinedihydrochlorideinbulkandcapsuleusingreversedphasehighperformancethinlayerchromatographydensitometry
_version_	1718445461298216960

SIMULTANEOUS DETERMINATION OF PROPRANOLOL HYDROCHLORIDE AND FLUNARIZINE DIHYDROCHLORIDE IN BULK AND CAPSULE USING REVERSED - PHASE HIGH -PERFORMANCE THIN LAYER CHROMATOGRAPHY / DENSITOMETRY

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