SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES

3-Chlorobenzothiophene-2-carbonyl chloride 1 was reacted with 4-aminoacetophenone in acetone to give compound 2. In order to prepare chalcones 3a-d, compound 2 was condensed with various aldehydes in the presence of KOH in DMF. These chalcones 3a-d on cyclization with urea, thiourea, hydroxylamine h...

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Autores principales:	AGANAGOWDA,GADADA, THAMYONGKIT,PATCHANITA, PETSOM,AMORN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Benzothiophene isoxazolines pyrimidines pyrazolines antimicrobial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100019
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spelling	oai:scielo:S0717-970720120001000192012-07-19SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVESAGANAGOWDA,GADADATHAMYONGKIT,PATCHANITAPETSOM,AMORN Benzothiophene isoxazolines pyrimidines pyrazolines antimicrobial activity 3-Chlorobenzothiophene-2-carbonyl chloride 1 was reacted with 4-aminoacetophenone in acetone to give compound 2. In order to prepare chalcones 3a-d, compound 2 was condensed with various aldehydes in the presence of KOH in DMF. These chalcones 3a-d on cyclization with urea, thiourea, hydroxylamine hydrochloride, phenyl hydrazines and hydrazine hydrate gave the corresponding oxapyrimidines 4a-d, isoxazolines 5a-d, pyrazoles 6a-h, pyrazolines 7a-d and thiopyrimidines 8a-d, respectively. The structures of all the synthesized compounds were confirmed by spectral data and had been screened for antibacterial activity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.1 20122012-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100019en10.4067/S0717-97072012000100019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Benzothiophene isoxazolines pyrimidines pyrazolines antimicrobial activity
spellingShingle	Benzothiophene isoxazolines pyrimidines pyrazolines antimicrobial activity AGANAGOWDA,GADADA THAMYONGKIT,PATCHANITA PETSOM,AMORN SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES
description	3-Chlorobenzothiophene-2-carbonyl chloride 1 was reacted with 4-aminoacetophenone in acetone to give compound 2. In order to prepare chalcones 3a-d, compound 2 was condensed with various aldehydes in the presence of KOH in DMF. These chalcones 3a-d on cyclization with urea, thiourea, hydroxylamine hydrochloride, phenyl hydrazines and hydrazine hydrate gave the corresponding oxapyrimidines 4a-d, isoxazolines 5a-d, pyrazoles 6a-h, pyrazolines 7a-d and thiopyrimidines 8a-d, respectively. The structures of all the synthesized compounds were confirmed by spectral data and had been screened for antibacterial activity.
author	AGANAGOWDA,GADADA THAMYONGKIT,PATCHANITA PETSOM,AMORN
author_facet	AGANAGOWDA,GADADA THAMYONGKIT,PATCHANITA PETSOM,AMORN
author_sort	AGANAGOWDA,GADADA
title	SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES
title_short	SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES
title_full	SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES
title_fullStr	SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES
title_full_unstemmed	SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES
title_sort	synthesis and antimicrobial activities of benzothiophene derivatives
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000100019
work_keys_str_mv	AT aganagowdagadada synthesisandantimicrobialactivitiesofbenzothiophenederivatives AT thamyongkitpatchanita synthesisandantimicrobialactivitiesofbenzothiophenederivatives AT petsomamorn synthesisandantimicrobialactivitiesofbenzothiophenederivatives
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SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF BENZOTHIOPHENE DERIVATIVES

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