NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION

The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the...

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Autores principales:	WARDAKHAN,WAGNAT WAHBA, SAMIR,EMAN MOHAMED
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	hydrazide-hydrazone pyridazine 1,2,3-triazole pyrazole anti-tumor
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200013
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spelling	oai:scielo:S0717-970720120002000132014-03-10NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATIONWARDAKHAN,WAGNAT WAHBASAMIR,EMAN MOHAMED hydrazide-hydrazone pyridazine 1,2,3-triazole pyrazole anti-tumor The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.2 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200013en10.4067/S0717-97072012000200013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	hydrazide-hydrazone pyridazine 1,2,3-triazole pyrazole anti-tumor
spellingShingle	hydrazide-hydrazone pyridazine 1,2,3-triazole pyrazole anti-tumor WARDAKHAN,WAGNAT WAHBA SAMIR,EMAN MOHAMED NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
description	The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.
author	WARDAKHAN,WAGNAT WAHBA SAMIR,EMAN MOHAMED
author_facet	WARDAKHAN,WAGNAT WAHBA SAMIR,EMAN MOHAMED
author_sort	WARDAKHAN,WAGNAT WAHBA
title	NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_short	NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_full	NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_fullStr	NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_full_unstemmed	NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_sort	new approaches for the synthesis of hydrazone derivatives and their antitumor evaluation
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200013
work_keys_str_mv	AT wardakhanwagnatwahba newapproachesforthesynthesisofhydrazonederivativesandtheirantitumorevaluation AT samiremanmohamed newapproachesforthesynthesisofhydrazonederivativesandtheirantitumorevaluation
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NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION

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