TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES

A convenient method using TMSCl (20 mol %) and microwave-induced technique for the synthesis of various benzimidazole is described. This has reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The synthesized compounds were evaluated for their i...

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Autores principales:	KARUVALAM,RANJITH. P, HARIDAS,KARICKAL. R, SHETTY,SUCHETHA. N
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Microwave TMSCl Benzimidazole Antibacterial activity Antifungal activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200014
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spelling	oai:scielo:S0717-970720120002000142014-03-10TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIESKARUVALAM,RANJITH. PHARIDAS,KARICKAL. RSHETTY,SUCHETHA. N Microwave TMSCl Benzimidazole Antibacterial activity Antifungal activity A convenient method using TMSCl (20 mol %) and microwave-induced technique for the synthesis of various benzimidazole is described. This has reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against four strains each. Preliminary results indicated that, compounds 3e, 3f, 3g, 3k, 3m, 3n and 3o demonstrated very good antimicrobial activity, comparable to the first line standard drugs. The most effective compounds have exhibited activity at MIC of 6.25 μg/mL.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.2 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200014en10.4067/S0717-97072012000200014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Microwave TMSCl Benzimidazole Antibacterial activity Antifungal activity
spellingShingle	Microwave TMSCl Benzimidazole Antibacterial activity Antifungal activity KARUVALAM,RANJITH. P HARIDAS,KARICKAL. R SHETTY,SUCHETHA. N TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES
description	A convenient method using TMSCl (20 mol %) and microwave-induced technique for the synthesis of various benzimidazole is described. This has reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against four strains each. Preliminary results indicated that, compounds 3e, 3f, 3g, 3k, 3m, 3n and 3o demonstrated very good antimicrobial activity, comparable to the first line standard drugs. The most effective compounds have exhibited activity at MIC of 6.25 μg/mL.
author	KARUVALAM,RANJITH. P HARIDAS,KARICKAL. R SHETTY,SUCHETHA. N
author_facet	KARUVALAM,RANJITH. P HARIDAS,KARICKAL. R SHETTY,SUCHETHA. N
author_sort	KARUVALAM,RANJITH. P
title	TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES
title_short	TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES
title_full	TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES
title_fullStr	TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES
title_full_unstemmed	TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES
title_sort	trimethylsilyl chloride catalyzed synthesis of substituted benzimidazoles using two phase system under microwave conditions, and their antimicrobial studies
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200014
work_keys_str_mv	AT karuvalamranjithp trimethylsilylchloridecatalyzedsynthesisofsubstitutedbenzimidazolesusingtwophasesystemundermicrowaveconditionsandtheirantimicrobialstudies AT haridaskarickalr trimethylsilylchloridecatalyzedsynthesisofsubstitutedbenzimidazolesusingtwophasesystemundermicrowaveconditionsandtheirantimicrobialstudies AT shettysuchethan trimethylsilylchloridecatalyzedsynthesisofsubstitutedbenzimidazolesusingtwophasesystemundermicrowaveconditionsandtheirantimicrobialstudies
_version_	1718445464975572992

TRIMETHYLSILYL CHLORIDE CATALYZED SYNTHESIS OF SUBSTITUTED BENZIMIDAZOLES USING TWO PHASE SYSTEM UNDER MICROWAVE CONDITIONS, AND THEIR ANTIMICROBIAL STUDIES

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