BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES

BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES

We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox...

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Autores principales: CAÑETE,A, ARMIJO,F, DEL VALLE,M. A, TAPIA,R.A, THEODULOZ,C, PESSOA,C. D, CANTUARIAS,L, RECABARREN,G
Lenguaje:English
Publicado: Sociedad Chilena de Química 2012
Materias:
Quinone
Electrochemical properties
Antiproliferative activity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200015
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spelling oai:scielo:S0717-970720120002000152014-03-10BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVESCAÑETE,AARMIJO,FDEL VALLE,M. ATAPIA,R.ATHEODULOZ,CPESSOA,C. DCANTUARIAS,LRECABARREN,G Quinone Electrochemical properties Antiproliferative activity We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (AGS) cell lines and human normal lung fibroblasts (MCR-5). The quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.2 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200015en10.4067/S0717-97072012000200015
institution Scielo Chile
collection Scielo Chile
language English
topic Quinone
Electrochemical properties
Antiproliferative activity
spellingShingle Quinone
Electrochemical properties
Antiproliferative activity
CAÑETE,A
ARMIJO,F
DEL VALLE,M. A
TAPIA,R.A
THEODULOZ,C
PESSOA,C. D
CANTUARIAS,L
RECABARREN,G
BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
description We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (AGS) cell lines and human normal lung fibroblasts (MCR-5). The quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.
author CAÑETE,A
ARMIJO,F
DEL VALLE,M. A
TAPIA,R.A
THEODULOZ,C
PESSOA,C. D
CANTUARIAS,L
RECABARREN,G
author_facet CAÑETE,A
ARMIJO,F
DEL VALLE,M. A
TAPIA,R.A
THEODULOZ,C
PESSOA,C. D
CANTUARIAS,L
RECABARREN,G
author_sort CAÑETE,A
title BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
title_short BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
title_full BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
title_fullStr BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
title_full_unstemmed BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES
title_sort biological activities and correlations tendency of electrochemical properties of some indolizino[1,2-b]quinoline derivatives
publisher Sociedad Chilena de Química
publishDate 2012
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200015
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