ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS

The construction and performance characteristics of simvastatin (SIM) selective electrodes were developed. Three types of electrodes: plastic membrane I, coated wire II, and coated graphite rod III were constructed based on the incorporation of simvastatin with phosphotungstic (PTA) or phosphomolybd...

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Autores principales:	ALARFAJ,NAWAL A, ALY,FATMA A, EL-TOHAMY,MAHA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Plastic membrane Coated wire electrode Coated graphite rod Ion-selective electrodes Simvastatin Potentiometric determination
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200018
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spelling	oai:scielo:S0717-970720120002000182014-03-10ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDSALARFAJ,NAWAL AALY,FATMA AEL-TOHAMY,MAHA Plastic membrane Coated wire electrode Coated graphite rod Ion-selective electrodes Simvastatin Potentiometric determination The construction and performance characteristics of simvastatin (SIM) selective electrodes were developed. Three types of electrodes: plastic membrane I, coated wire II, and coated graphite rod III were constructed based on the incorporation of simvastatin with phosphotungstic (PTA) or phosphomolybdic (PMA) acids and mixed ion pair (PTA/PMA) for the three electrodes, respectively. The influence of membrane composition, kind of plasticizer, type of ion-pair, pH of the test solution, soaking time, and foreign ions on the electrodes was investigated. The electrodes showed a Nernstain response with a mean calibration graph slope of 56.24±0.43, 55.44±0.14 and 58.93±0.34 mV decade-1 at 25°C over simvastatin concentration range from 1.0 x 10-6-5.0 x 10-2, 9.0 x 10-6-5.0 x 10-3 and 9.0 x 10-7-1.0 x 10-2 mol L-1, with detection limit of 5.0 x 10-7, 3.9 x 10-6 and 3.2 x 10-7 mol L-1 for electrode I, II and III, respectively. The pH range for the proposed electrodes was 4-7. The influence of possible interfering species such as common inorganic cations, many sugars, amino acids and a pharmacologically related drug 'ezetimibe' was studied. Statistical student's t-test and F test showed insignificant systematic error between proposed and official methods.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.2 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200018en10.4067/S0717-97072012000200018
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Plastic membrane Coated wire electrode Coated graphite rod Ion-selective electrodes Simvastatin Potentiometric determination
spellingShingle	Plastic membrane Coated wire electrode Coated graphite rod Ion-selective electrodes Simvastatin Potentiometric determination ALARFAJ,NAWAL A ALY,FATMA A EL-TOHAMY,MAHA ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
description	The construction and performance characteristics of simvastatin (SIM) selective electrodes were developed. Three types of electrodes: plastic membrane I, coated wire II, and coated graphite rod III were constructed based on the incorporation of simvastatin with phosphotungstic (PTA) or phosphomolybdic (PMA) acids and mixed ion pair (PTA/PMA) for the three electrodes, respectively. The influence of membrane composition, kind of plasticizer, type of ion-pair, pH of the test solution, soaking time, and foreign ions on the electrodes was investigated. The electrodes showed a Nernstain response with a mean calibration graph slope of 56.24±0.43, 55.44±0.14 and 58.93±0.34 mV decade-1 at 25°C over simvastatin concentration range from 1.0 x 10-6-5.0 x 10-2, 9.0 x 10-6-5.0 x 10-3 and 9.0 x 10-7-1.0 x 10-2 mol L-1, with detection limit of 5.0 x 10-7, 3.9 x 10-6 and 3.2 x 10-7 mol L-1 for electrode I, II and III, respectively. The pH range for the proposed electrodes was 4-7. The influence of possible interfering species such as common inorganic cations, many sugars, amino acids and a pharmacologically related drug 'ezetimibe' was studied. Statistical student's t-test and F test showed insignificant systematic error between proposed and official methods.
author	ALARFAJ,NAWAL A ALY,FATMA A EL-TOHAMY,MAHA
author_facet	ALARFAJ,NAWAL A ALY,FATMA A EL-TOHAMY,MAHA
author_sort	ALARFAJ,NAWAL A
title	ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
title_short	ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
title_full	ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
title_fullStr	ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
title_full_unstemmed	ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS
title_sort	electrochemical sensors for direct determination of simvastatin in pharmaceutical formulations and biological fluids
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200018
work_keys_str_mv	AT alarfajnawala electrochemicalsensorsfordirectdeterminationofsimvastatininpharmaceuticalformulationsandbiologicalfluids AT alyfatmaa electrochemicalsensorsfordirectdeterminationofsimvastatininpharmaceuticalformulationsandbiologicalfluids AT eltohamymaha electrochemicalsensorsfordirectdeterminationofsimvastatininpharmaceuticalformulationsandbiologicalfluids
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ELECTROCHEMICAL SENSORS FOR DIRECT DETERMINATION OF SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS

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