DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION

A simple, rapid, selective and sensitive RP-HPLC method was developed and validated for the estimation of triflusal. The method was carried out using 5-j1m particle size, C18-bonded silica column, quaternary pump and acetonitrile: 1 mM potassium dihydrogen phosphate (65:35 v/v) pH 3 as the mobile ph...

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Autores principales:	PATIL,VIJAYK, REDASANI,VIVEKKUMAR K, VISPUTE,KULDIP R, SURANA,SANJAY J
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Triflusal RP-HPLC Validation Specificity System suitability
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200026
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spelling	oai:scielo:S0717-970720120002000262014-03-10DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATIONPATIL,VIJAYKREDASANI,VIVEKKUMAR KVISPUTE,KULDIP RSURANA,SANJAY J Triflusal RP-HPLC Validation Specificity System suitability A simple, rapid, selective and sensitive RP-HPLC method was developed and validated for the estimation of triflusal. The method was carried out using 5-j1m particle size, C18-bonded silica column, quaternary pump and acetonitrile: 1 mM potassium dihydrogen phosphate (65:35 v/v) pH 3 as the mobile phase with UV detection at 226 nm. The proposed method is advantageous as it follows isocratic elution in short run time (10 min). The result obtained shown that the method best fits for estimation of drug in capsule formulation and thus can be used for its routine analysis. The newly developed method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.2 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200026en10.4067/S0717-97072012000200026
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Triflusal RP-HPLC Validation Specificity System suitability
spellingShingle	Triflusal RP-HPLC Validation Specificity System suitability PATIL,VIJAYK REDASANI,VIVEKKUMAR K VISPUTE,KULDIP R SURANA,SANJAY J DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION
description	A simple, rapid, selective and sensitive RP-HPLC method was developed and validated for the estimation of triflusal. The method was carried out using 5-j1m particle size, C18-bonded silica column, quaternary pump and acetonitrile: 1 mM potassium dihydrogen phosphate (65:35 v/v) pH 3 as the mobile phase with UV detection at 226 nm. The proposed method is advantageous as it follows isocratic elution in short run time (10 min). The result obtained shown that the method best fits for estimation of drug in capsule formulation and thus can be used for its routine analysis. The newly developed method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.
author	PATIL,VIJAYK REDASANI,VIVEKKUMAR K VISPUTE,KULDIP R SURANA,SANJAY J
author_facet	PATIL,VIJAYK REDASANI,VIVEKKUMAR K VISPUTE,KULDIP R SURANA,SANJAY J
author_sort	PATIL,VIJAYK
title	DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION
title_short	DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION
title_full	DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION
title_fullStr	DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION
title_full_unstemmed	DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION
title_sort	development and validation of rp-hplc method for the estimation of triflusal in bulk and in capsule formulation
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200026
work_keys_str_mv	AT patilvijayk developmentandvalidationofrphplcmethodfortheestimationoftriflusalinbulkandincapsuleformulation AT redasanivivekkumark developmentandvalidationofrphplcmethodfortheestimationoftriflusalinbulkandincapsuleformulation AT visputekuldipr developmentandvalidationofrphplcmethodfortheestimationoftriflusalinbulkandincapsuleformulation AT suranasanjayj developmentandvalidationofrphplcmethodfortheestimationoftriflusalinbulkandincapsuleformulation
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION

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