ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS

New bis (bidentate) azine NNN'N' donor ligand was prepared by linking (1Z,1'Z)-1,1'-{propane-1,3-diylbis[oxybenzene-4,1-diyl(1Z)eth-1-yl-1-ylidene]} dihydra-zine to pyridine-2-carbaldehyde. Two kinds of copper(II) and nickel (II) complexes with different stoichiometries were prep...

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Autores principales:	Kulaksizoğlu,Sultan, Gökçe,Cansu, Gup,Ramazan
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	azine complexes DNA-interaction extraction heavy metals dichromate anions
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300004
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spelling	oai:scielo:S0717-970720120003000042019-02-19ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONSKulaksizoğlu,SultanGökçe,CansuGup,Ramazan azine complexes DNA-interaction extraction heavy metals dichromate anions New bis (bidentate) azine NNN'N' donor ligand was prepared by linking (1Z,1'Z)-1,1'-{propane-1,3-diylbis[oxybenzene-4,1-diyl(1Z)eth-1-yl-1-ylidene]} dihydra-zine to pyridine-2-carbaldehyde. Two kinds of copper(II) and nickel (II) complexes with different stoichiometries were prepared. Reaction of bis(azine) ligand with Cu(II) and Ni(II) chloride with 1:1 molar ratio gave azine complexes with stoichiometry [M(L)Cl2] while 2:1 molar ratio reaction of Cu(II) and Ni(II) chloride with bis(azine) composed binuclear copper complexes with general stoichiometry [M2(L)Cl4]. The structures of both bis-azine ligand and its complexes were identified by elemental analysis, infrared spectra, UV-Vis electronic absorption spectra and magnetic susceptibility measurements, TGA and powder XRD. DNA binding and DNA cleavage activities of the synthesized metal complexes were examined by using UV-vis titration and agarose gel electrophoresis, respectively. The results indicate that all the complexes bind significantly calf thymus DNA and cleavage pBR322 DNA. Furthermore, the complexing properties of the bis-azine ligand toward selected transition metal cations and dichromate anions were also reported.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300004en10.4067/S0717-97072012000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	azine complexes DNA-interaction extraction heavy metals dichromate anions
spellingShingle	azine complexes DNA-interaction extraction heavy metals dichromate anions Kulaksizoğlu,Sultan Gökçe,Cansu Gup,Ramazan ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS
description	New bis (bidentate) azine NNN'N' donor ligand was prepared by linking (1Z,1'Z)-1,1'-{propane-1,3-diylbis[oxybenzene-4,1-diyl(1Z)eth-1-yl-1-ylidene]} dihydra-zine to pyridine-2-carbaldehyde. Two kinds of copper(II) and nickel (II) complexes with different stoichiometries were prepared. Reaction of bis(azine) ligand with Cu(II) and Ni(II) chloride with 1:1 molar ratio gave azine complexes with stoichiometry [M(L)Cl2] while 2:1 molar ratio reaction of Cu(II) and Ni(II) chloride with bis(azine) composed binuclear copper complexes with general stoichiometry [M2(L)Cl4]. The structures of both bis-azine ligand and its complexes were identified by elemental analysis, infrared spectra, UV-Vis electronic absorption spectra and magnetic susceptibility measurements, TGA and powder XRD. DNA binding and DNA cleavage activities of the synthesized metal complexes were examined by using UV-vis titration and agarose gel electrophoresis, respectively. The results indicate that all the complexes bind significantly calf thymus DNA and cleavage pBR322 DNA. Furthermore, the complexing properties of the bis-azine ligand toward selected transition metal cations and dichromate anions were also reported.
author	Kulaksizoğlu,Sultan Gökçe,Cansu Gup,Ramazan
author_facet	Kulaksizoğlu,Sultan Gökçe,Cansu Gup,Ramazan
author_sort	Kulaksizoğlu,Sultan
title	ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS
title_short	ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS
title_full	ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS
title_fullStr	ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS
title_full_unstemmed	ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS
title_sort	asymmetric bis(bidentate) azine ligand and transition metal complexes: synthesis, characterization, dna-binding and cleavage studies and extraction properties for selected metals and dichromate anions
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300004
work_keys_str_mv	AT kulaksizo287lusultan asymmetricbisbidentateazineligandandtransitionmetalcomplexessynthesischaracterizationdnabindingandcleavagestudiesandextractionpropertiesforselectedmetalsanddichromateanions AT gokcecansu asymmetricbisbidentateazineligandandtransitionmetalcomplexessynthesischaracterizationdnabindingandcleavagestudiesandextractionpropertiesforselectedmetalsanddichromateanions AT gupramazan asymmetricbisbidentateazineligandandtransitionmetalcomplexessynthesischaracterizationdnabindingandcleavagestudiesandextractionpropertiesforselectedmetalsanddichromateanions
_version_	1718445468392882176

ASYMMETRIC BIS(BIDENTATE) AZINE LIGAND AND TRANSITION METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA-BINDING AND CLEAVAGE STUDIES AND EXTRACTION PROPERTIES FOR SELECTED METALS AND DICHROMATE ANIONS

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