SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY

A number of quinolone-3-acetic acids were synthesized by cyclocondensation of substituted anilines with diethyl acetylsuccinate in the presence of phosphorous pentoxide and followed by base hydrolysis of the resultant esters to form respective acids. All synthesized compounds were found to exhibit a...

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Autores principales:	Chattha,Fauzia Anjum, Munawar,Munawar Ali, Ashraf,Muhammad, Nagra,Saeed Ahmad, Mehr-Un-Nisa, Fatima,Ismat
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	2-methyl-4-quinolone-3-acetic acid, 4-oxo-2-methylquinoline-3-acetic acids antibacterial activity gram positive gram negative bacterial strains
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300008
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spelling	oai:scielo:S0717-970720120003000082019-02-19SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITYChattha,Fauzia AnjumMunawar,Munawar AliAshraf,MuhammadNagra,Saeed AhmadMehr-Un-Nisa,Fatima,Ismat 2-methyl-4-quinolone-3-acetic acid, 4-oxo-2-methylquinoline-3-acetic acids antibacterial activity gram positive gram negative bacterial strains A number of quinolone-3-acetic acids were synthesized by cyclocondensation of substituted anilines with diethyl acetylsuccinate in the presence of phosphorous pentoxide and followed by base hydrolysis of the resultant esters to form respective acids. All synthesized compounds were found to exhibit antibacterial activities against a range of gram-positive (Bacillus subtilis, Staphylococcus aureus) and gram-negative bacteria (Shigella sonnei, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) by broth dilution method. All the compounds exhibited antibacterial activities comparable to fluoroquinolones and in some cases even better activity was found. These findings suggest a great potential of these compounds for screening and use as antibacterial compounds for further studies with a battery of bacteria.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300008en10.4067/S0717-97072012000300008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	2-methyl-4-quinolone-3-acetic acid, 4-oxo-2-methylquinoline-3-acetic acids antibacterial activity gram positive gram negative bacterial strains
spellingShingle	2-methyl-4-quinolone-3-acetic acid, 4-oxo-2-methylquinoline-3-acetic acids antibacterial activity gram positive gram negative bacterial strains Chattha,Fauzia Anjum Munawar,Munawar Ali Ashraf,Muhammad Nagra,Saeed Ahmad Mehr-Un-Nisa, Fatima,Ismat SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY
description	A number of quinolone-3-acetic acids were synthesized by cyclocondensation of substituted anilines with diethyl acetylsuccinate in the presence of phosphorous pentoxide and followed by base hydrolysis of the resultant esters to form respective acids. All synthesized compounds were found to exhibit antibacterial activities against a range of gram-positive (Bacillus subtilis, Staphylococcus aureus) and gram-negative bacteria (Shigella sonnei, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) by broth dilution method. All the compounds exhibited antibacterial activities comparable to fluoroquinolones and in some cases even better activity was found. These findings suggest a great potential of these compounds for screening and use as antibacterial compounds for further studies with a battery of bacteria.
author	Chattha,Fauzia Anjum Munawar,Munawar Ali Ashraf,Muhammad Nagra,Saeed Ahmad Mehr-Un-Nisa, Fatima,Ismat
author_facet	Chattha,Fauzia Anjum Munawar,Munawar Ali Ashraf,Muhammad Nagra,Saeed Ahmad Mehr-Un-Nisa, Fatima,Ismat
author_sort	Chattha,Fauzia Anjum
title	SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY
title_short	SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY
title_full	SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY
title_fullStr	SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY
title_full_unstemmed	SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY
title_sort	synthesis of 2-methyl4quinolone-3-acetic acids with potential antibacterial activity
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300008
work_keys_str_mv	AT chatthafauziaanjum synthesisof2methyl4quinolone3aceticacidswithpotentialantibacterialactivity AT munawarmunawarali synthesisof2methyl4quinolone3aceticacidswithpotentialantibacterialactivity AT ashrafmuhammad synthesisof2methyl4quinolone3aceticacidswithpotentialantibacterialactivity AT nagrasaeedahmad synthesisof2methyl4quinolone3aceticacidswithpotentialantibacterialactivity AT mehrunnisa synthesisof2methyl4quinolone3aceticacidswithpotentialantibacterialactivity AT fatimaismat synthesisof2methyl4quinolone3aceticacidswithpotentialantibacterialactivity
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SYNTHESIS OF 2-METHYL4QUINOLONE-3-ACETIC ACIDS WITH POTENTIAL ANTIBACTERIAL ACTIVITY

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