SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE

A series of biologically active Mannich bases with heteroaromatic ring system have been synthesized employing Mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy}methyl] 6-9 dihydro-3H-purin-6-one ( potent drug) with biologically active sulphonamides and secondary amines. They were analy...

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Autores principales:	JOSHI,SHEELA, BILGAIYAN,PURTI, PATHAK,ANJU
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purin-6-one (Ganciclovir) Sulphonamides Mannich reaction Mannich bases Antibacterial activity LD50 test
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300017
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spelling	oai:scielo:S0717-970720120003000172019-02-19SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONEJOSHI,SHEELABILGAIYAN,PURTIPATHAK,ANJU 2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purin-6-one (Ganciclovir) Sulphonamides Mannich reaction Mannich bases Antibacterial activity LD50 test A series of biologically active Mannich bases with heteroaromatic ring system have been synthesized employing Mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy}methyl] 6-9 dihydro-3H-purin-6-one ( potent drug) with biologically active sulphonamides and secondary amines. They were analyzed by elemental analysis and characterized by spectral studies- UV, IR, ¹H NMR, Powder X-ray diffraction and Scanning Electron Microscopy. The Mannich bases were screened for their antibacterial activity against various gram + and gram - bacteria. The results had shown that the Mannich bases are quiet active against pathogens under study at varying concentrations. The toxicity of synthesized Mannich bases was ascertained by LD50 test.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.3 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300017en10.4067/S0717-97072012000300017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purin-6-one (Ganciclovir) Sulphonamides Mannich reaction Mannich bases Antibacterial activity LD50 test
spellingShingle	2-amino-9 [{(1,3 di hydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3H-purin-6-one (Ganciclovir) Sulphonamides Mannich reaction Mannich bases Antibacterial activity LD50 test JOSHI,SHEELA BILGAIYAN,PURTI PATHAK,ANJU SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE
description	A series of biologically active Mannich bases with heteroaromatic ring system have been synthesized employing Mannich reaction of 2-amino-9 [{(1,3 dihydroxy propane-2yl) oxy}methyl] 6-9 dihydro-3H-purin-6-one ( potent drug) with biologically active sulphonamides and secondary amines. They were analyzed by elemental analysis and characterized by spectral studies- UV, IR, ¹H NMR, Powder X-ray diffraction and Scanning Electron Microscopy. The Mannich bases were screened for their antibacterial activity against various gram + and gram - bacteria. The results had shown that the Mannich bases are quiet active against pathogens under study at varying concentrations. The toxicity of synthesized Mannich bases was ascertained by LD50 test.
author	JOSHI,SHEELA BILGAIYAN,PURTI PATHAK,ANJU
author_facet	JOSHI,SHEELA BILGAIYAN,PURTI PATHAK,ANJU
author_sort	JOSHI,SHEELA
title	SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE
title_short	SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE
title_full	SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE
title_fullStr	SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE
title_full_unstemmed	SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE
title_sort	synthesis and in-vitro study of some medicinally important mannich bases derived from 2-amino-9 [{(1, 3 dihydroxy propane-2yl) oxy} methyl] 6-9 dihydro-3h-purin-6-one
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000300017
work_keys_str_mv	AT joshisheela synthesisandinvitrostudyofsomemedicinallyimportantmannichbasesderivedfrom2amino913dihydroxypropane2yloxymethyl69dihydro3hpurin6one AT bilgaiyanpurti synthesisandinvitrostudyofsomemedicinallyimportantmannichbasesderivedfrom2amino913dihydroxypropane2yloxymethyl69dihydro3hpurin6one AT pathakanju synthesisandinvitrostudyofsomemedicinallyimportantmannichbasesderivedfrom2amino913dihydroxypropane2yloxymethyl69dihydro3hpurin6one
_version_	1718445470677729280

SYNTHESIS AND IN-VITRO STUDY OF SOME MEDICINALLY IMPORTANT MANNICH BASES DERIVED FROM 2-AMINO-9 [{(1, 3 DIHYDROXY PROPANE-2YL) OXY} METHYL] 6-9 DIHYDRO-3H-PURIN-6-ONE

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