SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS

Four simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for simultaneous determination of ambroxol, guaiphenesin and levosalbutamol sulphate, in pure and pharmaceutical formulations without any prior separation or purification step. The methods ar...

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Autores principales:	GAGANDEEP, GILL,NAVDEEP KAUR, KARAN, SARMA,G S, THAKKAR,ARTI
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Simultaneous equation method Derivative ratio spectra zero crossing spectrophotometry Double divisor ratio spectra derivative spectrophotometry Ambroxol Guaiphenesin Levosalbutamol sulphate
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400021
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spelling	oai:scielo:S0717-970720120004000212013-04-04SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODSGAGANDEEP,GILL,NAVDEEP KAURKARAN,SARMA,G STHAKKAR,ARTI Simultaneous equation method Derivative ratio spectra zero crossing spectrophotometry Double divisor ratio spectra derivative spectrophotometry Ambroxol Guaiphenesin Levosalbutamol sulphate Four simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for simultaneous determination of ambroxol, guaiphenesin and levosalbutamol sulphate, in pure and pharmaceutical formulations without any prior separation or purification step. The methods are first derivative zero crossing spectrophotometry, simultaneous equation, derivative ratio spectra zero crossing and double divisor ratio spectra derivative method. Developed methods show best results in terms of linearity, accuracy, precision, LOD and LOQ for standard laboratory mixtures of pure drugs and marketed formulations. Common excipients and additives did not interfere in determinations of these APIs. Results obtained by the proposed methods have been statistically compared by means of student t-test.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.4 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400021en10.4067/S0717-97072012000400021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Simultaneous equation method Derivative ratio spectra zero crossing spectrophotometry Double divisor ratio spectra derivative spectrophotometry Ambroxol Guaiphenesin Levosalbutamol sulphate
spellingShingle	Simultaneous equation method Derivative ratio spectra zero crossing spectrophotometry Double divisor ratio spectra derivative spectrophotometry Ambroxol Guaiphenesin Levosalbutamol sulphate GAGANDEEP, GILL,NAVDEEP KAUR KARAN, SARMA,G S THAKKAR,ARTI SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS
description	Four simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for simultaneous determination of ambroxol, guaiphenesin and levosalbutamol sulphate, in pure and pharmaceutical formulations without any prior separation or purification step. The methods are first derivative zero crossing spectrophotometry, simultaneous equation, derivative ratio spectra zero crossing and double divisor ratio spectra derivative method. Developed methods show best results in terms of linearity, accuracy, precision, LOD and LOQ for standard laboratory mixtures of pure drugs and marketed formulations. Common excipients and additives did not interfere in determinations of these APIs. Results obtained by the proposed methods have been statistically compared by means of student t-test.
author	GAGANDEEP, GILL,NAVDEEP KAUR KARAN, SARMA,G S THAKKAR,ARTI
author_facet	GAGANDEEP, GILL,NAVDEEP KAUR KARAN, SARMA,G S THAKKAR,ARTI
author_sort	GAGANDEEP,
title	SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS
title_short	SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS
title_full	SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS
title_fullStr	SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS
title_full_unstemmed	SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS
title_sort	simultaneous determination of ambroxol, guaiphenesin and levosalbutamol sulphate in pharmaceutical formulations with the use of four rapid derivative spectrophotometric methods
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400021
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SIMULTANEOUS DETERMINATION OF AMBROXOL, GUAIPHENESIN AND LEVOSALBUTAMOL SULPHATE IN PHARMACEUTICAL FORMULATIONS WITH THE USE OF FOUR RAPID DERIVATIVE SPECTROPHOTOMETRIC METHODS

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