SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS

Six spectrophotometric methods for determination of eszopiclone have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B, C and D are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue(BTB), Bromop...

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Autores principales:	CHENNAIAH,M, VEERAIAH,T, VENKATESHWARLU,G
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2012
Materias:	Spectrophotometry Eszopiclone Bromothymol blue Bromophenol blue Bromocresol green Bromocresol purple Iodine Alkaline KMnO4
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400025
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spelling	oai:scielo:S0717-970720120004000252013-04-04SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMSCHENNAIAH,MVEERAIAH,TVENKATESHWARLU,G Spectrophotometry Eszopiclone Bromothymol blue Bromophenol blue Bromocresol green Bromocresol purple Iodine Alkaline KMnO4 Six spectrophotometric methods for determination of eszopiclone have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B, C and D are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue(BTB), Bromophenol blue(BPB), Bromocresol green(BCG) and Bromocresol purple(BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method E depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method F is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precession indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.4 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400025en10.4067/S0717-97072012000400025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spectrophotometry Eszopiclone Bromothymol blue Bromophenol blue Bromocresol green Bromocresol purple Iodine Alkaline KMnO4
spellingShingle	Spectrophotometry Eszopiclone Bromothymol blue Bromophenol blue Bromocresol green Bromocresol purple Iodine Alkaline KMnO4 CHENNAIAH,M VEERAIAH,T VENKATESHWARLU,G SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS
description	Six spectrophotometric methods for determination of eszopiclone have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B, C and D are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue(BTB), Bromophenol blue(BPB), Bromocresol green(BCG) and Bromocresol purple(BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method E depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method F is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precession indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals.
author	CHENNAIAH,M VEERAIAH,T VENKATESHWARLU,G
author_facet	CHENNAIAH,M VEERAIAH,T VENKATESHWARLU,G
author_sort	CHENNAIAH,M
title	SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS
title_short	SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS
title_full	SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS
title_fullStr	SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS
title_full_unstemmed	SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS
title_sort	spectrophotometric determination of eszopiclone in pure and pharmaceutical forms
publisher	Sociedad Chilena de Química
publishDate	2012
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400025
work_keys_str_mv	AT chennaiahm spectrophotometricdeterminationofeszopicloneinpureandpharmaceuticalforms AT veeraiaht spectrophotometricdeterminationofeszopicloneinpureandpharmaceuticalforms AT venkateshwarlug spectrophotometricdeterminationofeszopicloneinpureandpharmaceuticalforms
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SPECTROPHOTOMETRIC DETERMINATION OF ESZOPICLONE IN PURE AND PHARMACEUTICAL FORMS

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