SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES

SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES

Some new Schiff-bases derived from condensation of 3-hydrazono-2-oxo-2,3-dihydroindol-1-yl)-acetic acid hydrazide (3) with benzaldehyde, p-methoxy-benzaldehyde and p-chlorobenzaldehyde have been synthesized in high yields via refluxing in EtOH in the presence of catalytic amount of acetic acid. The...

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Autores principales: SALLAM,S.A, IBRAHIM,E.S.I, ANWAR,M.I
Lenguaje:English
Publicado: Sociedad Chilena de Química 2012
Materias:
Isatin Schiff-bases
Cu(II), Zn(II), Mn(II) complexes
spectral
thermal properties and biological activity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400030
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spelling oai:scielo:S0717-970720120004000302013-04-04SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASESSALLAM,S.AIBRAHIM,E.S.IANWAR,M.I Isatin Schiff-bases Cu(II), Zn(II), Mn(II) complexes spectral thermal properties and biological activity Some new Schiff-bases derived from condensation of 3-hydrazono-2-oxo-2,3-dihydroindol-1-yl)-acetic acid hydrazide (3) with benzaldehyde, p-methoxy-benzaldehyde and p-chlorobenzaldehyde have been synthesized in high yields via refluxing in EtOH in the presence of catalytic amount of acetic acid. The synthesized compounds have been characterized by elemental analysis, IR, iH-NMR and mass spectra. Cu(II), Zn(II), Mn(II) and Fe(III) complexes of the synthesized compounds were prepared and characterized by elemental analysis, conductivity measurements, IR, UV-Vis. spectra and magnetic moment measurements. TGA and DTA confirm the chemical formulation of the complexes and their thermal decomposition were evaluated. Antimicrobial activity of the synthesized compounds have been screened using the desk diffusion method with different strains of bacteria: Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and Proteus volgaris were used.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.4 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400030en10.4067/S0717-97072012000400030
institution Scielo Chile
collection Scielo Chile
language English
topic Isatin Schiff-bases
Cu(II), Zn(II), Mn(II) complexes
spectral
thermal properties and biological activity
spellingShingle Isatin Schiff-bases
Cu(II), Zn(II), Mn(II) complexes
spectral
thermal properties and biological activity
SALLAM,S.A
IBRAHIM,E.S.I
ANWAR,M.I
SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES
description Some new Schiff-bases derived from condensation of 3-hydrazono-2-oxo-2,3-dihydroindol-1-yl)-acetic acid hydrazide (3) with benzaldehyde, p-methoxy-benzaldehyde and p-chlorobenzaldehyde have been synthesized in high yields via refluxing in EtOH in the presence of catalytic amount of acetic acid. The synthesized compounds have been characterized by elemental analysis, IR, iH-NMR and mass spectra. Cu(II), Zn(II), Mn(II) and Fe(III) complexes of the synthesized compounds were prepared and characterized by elemental analysis, conductivity measurements, IR, UV-Vis. spectra and magnetic moment measurements. TGA and DTA confirm the chemical formulation of the complexes and their thermal decomposition were evaluated. Antimicrobial activity of the synthesized compounds have been screened using the desk diffusion method with different strains of bacteria: Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and Proteus volgaris were used.
author SALLAM,S.A
IBRAHIM,E.S.I
ANWAR,M.I
author_facet SALLAM,S.A
IBRAHIM,E.S.I
ANWAR,M.I
author_sort SALLAM,S.A
title SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES
title_short SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES
title_full SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES
title_fullStr SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES
title_full_unstemmed SYNTHESIS, COMPLEXATION AND BIOLOGICAL ACTIVITY OF NEW ISATIN SCHIFF_BASES
title_sort synthesis, complexation and biological activity of new isatin schiff_bases
publisher Sociedad Chilena de Química
publishDate 2012
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000400030
work_keys_str_mv AT sallamsa synthesiscomplexationandbiologicalactivityofnewisatinschiffbases
AT ibrahimesi synthesiscomplexationandbiologicalactivityofnewisatinschiffbases
AT anwarmi synthesiscomplexationandbiologicalactivityofnewisatinschiffbases
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