SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES

Four novel pleuromutilin derivatives with butyl amine group in the C-14 side-chain were designed, synthesized and confirmed by FT-IR, ¹H-NMR and HR-MS. The results of antibacterial activity showed that the antibacterial activity of pleuromutilin derivatives could be affected by the steric hindrance...

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Autores principales:	TANG,YOUZHI, LUO,JIAN, CHEN,XIAOJIE, WANG,BO, SHEN,XIANGGUANG, LIU,JIANHUA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	pleuromutilin derivatives antibacterial Staphylococcus aureus
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100008
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spelling	oai:scielo:S0717-970720130001000082014-09-09SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVESTANG,YOUZHILUO,JIANCHEN,XIAOJIEWANG,BOSHEN,XIANGGUANGLIU,JIANHUA pleuromutilin derivatives antibacterial Staphylococcus aureus Four novel pleuromutilin derivatives with butyl amine group in the C-14 side-chain were designed, synthesized and confirmed by FT-IR, ¹H-NMR and HR-MS. The results of antibacterial activity showed that the antibacterial activity of pleuromutilin derivatives could be affected by the steric hindrance of their C-14 side-chain.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.1 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100008en10.4067/S0717-97072013000100008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	pleuromutilin derivatives antibacterial Staphylococcus aureus
spellingShingle	pleuromutilin derivatives antibacterial Staphylococcus aureus TANG,YOUZHI LUO,JIAN CHEN,XIAOJIE WANG,BO SHEN,XIANGGUANG LIU,JIANHUA SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES
description	Four novel pleuromutilin derivatives with butyl amine group in the C-14 side-chain were designed, synthesized and confirmed by FT-IR, ¹H-NMR and HR-MS. The results of antibacterial activity showed that the antibacterial activity of pleuromutilin derivatives could be affected by the steric hindrance of their C-14 side-chain.
author	TANG,YOUZHI LUO,JIAN CHEN,XIAOJIE WANG,BO SHEN,XIANGGUANG LIU,JIANHUA
author_facet	TANG,YOUZHI LUO,JIAN CHEN,XIAOJIE WANG,BO SHEN,XIANGGUANG LIU,JIANHUA
author_sort	TANG,YOUZHI
title	SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES
title_short	SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES
title_full	SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES
title_fullStr	SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES
title_full_unstemmed	SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES
title_sort	synthesis and in vitro antibacterial activity of four novel pleuromutilin derivatives
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100008
work_keys_str_mv	AT tangyouzhi synthesisandinvitroantibacterialactivityoffournovelpleuromutilinderivatives AT luojian synthesisandinvitroantibacterialactivityoffournovelpleuromutilinderivatives AT chenxiaojie synthesisandinvitroantibacterialactivityoffournovelpleuromutilinderivatives AT wangbo synthesisandinvitroantibacterialactivityoffournovelpleuromutilinderivatives AT shenxiangguang synthesisandinvitroantibacterialactivityoffournovelpleuromutilinderivatives AT liujianhua synthesisandinvitroantibacterialactivityoffournovelpleuromutilinderivatives
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SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF FOUR NOVEL PLEUROMUTILIN DERIVATIVES

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