PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188

Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	SHARMA,ANSHU, JAIN,CHANDRA PRAKASH, TANWAR,YUVERAJ SINGH
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100012
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072013000100012
record_format	dspace
spelling	oai:scielo:S0717-970720130001000122014-09-09PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188SHARMA,ANSHUJAIN,CHANDRA PRAKASHTANWAR,YUVERAJ SINGHSolid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carvedilol for enhancement of oral bioavailability. In the present investigation solid dispersions with poloxamer 188 were prepared by fusion method. The physical mixture and solid dispersion(s) were characterized for drug-carrier interaction, drug content, solubility and dissolution rate. The solubility of drug increased with increasing polymer concentration. The dissolution rate was substantially improved for carvedilol from its solid dispersion compared with pure drug and physical mixture. As indicated from X-ray diffraction pattern, DSC thermograms and SEM photographs, carvedilol was in the amorphous form, which confirmed the better dissolution rate of solid dispersions. FTIR results proved no chemical interaction between carvedilol and poloxamer 188. SEM images showed a novel morphology of solid dispersion compared with pure drug. The solid dispersion was stable under accelerated storage conditions.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.1 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100012en10.4067/S0717-97072013000100012
institution	Scielo Chile
collection	Scielo Chile
language	English
description	Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carvedilol for enhancement of oral bioavailability. In the present investigation solid dispersions with poloxamer 188 were prepared by fusion method. The physical mixture and solid dispersion(s) were characterized for drug-carrier interaction, drug content, solubility and dissolution rate. The solubility of drug increased with increasing polymer concentration. The dissolution rate was substantially improved for carvedilol from its solid dispersion compared with pure drug and physical mixture. As indicated from X-ray diffraction pattern, DSC thermograms and SEM photographs, carvedilol was in the amorphous form, which confirmed the better dissolution rate of solid dispersions. FTIR results proved no chemical interaction between carvedilol and poloxamer 188. SEM images showed a novel morphology of solid dispersion compared with pure drug. The solid dispersion was stable under accelerated storage conditions.
author	SHARMA,ANSHU JAIN,CHANDRA PRAKASH TANWAR,YUVERAJ SINGH
spellingShingle	SHARMA,ANSHU JAIN,CHANDRA PRAKASH TANWAR,YUVERAJ SINGH PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188
author_facet	SHARMA,ANSHU JAIN,CHANDRA PRAKASH TANWAR,YUVERAJ SINGH
author_sort	SHARMA,ANSHU
title	PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188
title_short	PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188
title_full	PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188
title_fullStr	PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188
title_full_unstemmed	PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188
title_sort	preparation and characterization of solid dispersions of carvedilol with poloxamer 188
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100012
work_keys_str_mv	AT sharmaanshu preparationandcharacterizationofsoliddispersionsofcarvedilolwithpoloxamer188 AT jainchandraprakash preparationandcharacterizationofsoliddispersionsofcarvedilolwithpoloxamer188 AT tanwaryuverajsingh preparationandcharacterizationofsoliddispersionsofcarvedilolwithpoloxamer188
_version_	1718445480910782464

PREPARATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF CARVEDILOL WITH POLOXAMER 188

Ejemplares similares