SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST

An efficient, environmentally benign, highly facile and convenient synthetic protocol for the selective t-butyl carboxylation of aliphatic, aromatic and heterocyclic amines using AmberlystR A 21 catalyst; a mild basic solid resin under solvent free conditions is reported. This method explores severa...

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Autores principales:	TEKALE,SUNIL U, KAUTHALE,SUSHAMA S, PAWAR,RAJENDRA P
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	AmberlystR A 21 Amine t-butyl dicarbonate Carbamate Heterogeneous catalyst
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100025
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spelling	oai:scielo:S0717-970720130001000252014-09-09SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYSTTEKALE,SUNIL UKAUTHALE,SUSHAMA SPAWAR,RAJENDRA P AmberlystR A 21 Amine t-butyl dicarbonate Carbamate Heterogeneous catalyst An efficient, environmentally benign, highly facile and convenient synthetic protocol for the selective t-butyl carboxylation of aliphatic, aromatic and heterocyclic amines using AmberlystR A 21 catalyst; a mild basic solid resin under solvent free conditions is reported. This method explores several advantages such as reusability of the heterogeneous catalyst, cleaner reaction profile, mild and solvent free system, short reaction time, operational simplicity, high conversions , excellent product yields and low cost of the catalyst. Furthermore since the catalyst is mild basic, decomposition of the carbamate formed is not observed if the reaction is continued for prolonged time as in the case of Lewis acid catalyzed N-Boc protection. This makes the present protocol a useful and attractive for N-Boc protection of amines.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.1 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100025en10.4067/S0717-97072013000100025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	AmberlystR A 21 Amine t-butyl dicarbonate Carbamate Heterogeneous catalyst
spellingShingle	AmberlystR A 21 Amine t-butyl dicarbonate Carbamate Heterogeneous catalyst TEKALE,SUNIL U KAUTHALE,SUSHAMA S PAWAR,RAJENDRA P SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST
description	An efficient, environmentally benign, highly facile and convenient synthetic protocol for the selective t-butyl carboxylation of aliphatic, aromatic and heterocyclic amines using AmberlystR A 21 catalyst; a mild basic solid resin under solvent free conditions is reported. This method explores several advantages such as reusability of the heterogeneous catalyst, cleaner reaction profile, mild and solvent free system, short reaction time, operational simplicity, high conversions , excellent product yields and low cost of the catalyst. Furthermore since the catalyst is mild basic, decomposition of the carbamate formed is not observed if the reaction is continued for prolonged time as in the case of Lewis acid catalyzed N-Boc protection. This makes the present protocol a useful and attractive for N-Boc protection of amines.
author	TEKALE,SUNIL U KAUTHALE,SUSHAMA S PAWAR,RAJENDRA P
author_facet	TEKALE,SUNIL U KAUTHALE,SUSHAMA S PAWAR,RAJENDRA P
author_sort	TEKALE,SUNIL U
title	SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST
title_short	SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST
title_full	SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST
title_fullStr	SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST
title_full_unstemmed	SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST
title_sort	solvent free n-boc protection of amines using amberlyst r a 21 solid base resin as a reusable heterogeneous catalyst
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100025
work_keys_str_mv	AT tekalesunilu solventfreenbocprotectionofaminesusingamberlystra21solidbaseresinasareusableheterogeneouscatalyst AT kauthalesushamas solventfreenbocprotectionofaminesusingamberlystra21solidbaseresinasareusableheterogeneouscatalyst AT pawarrajendrap solventfreenbocprotectionofaminesusingamberlystra21solidbaseresinasareusableheterogeneouscatalyst
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SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYST R A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST

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