SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES

A new Schiff base ligands (H2L¹-H2L³) was synthesized by the condensation reaction of 4-acyl pyrazolones and 2-benzothiazolyl thiosemicarbazide. The ruthenium(II) Schiff base complexes were prepared by the interaction of the ligands with [RuHCl(CO)(EPh3)2(B)] (E=P/As; B=PPh3/AsPh3/py). They were cha...

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Autores principales:	SATHIYARAJ,SUBBAIYAN, JAYABALAKRISHNAN,CHINNASAMY
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Ruthenium(II) complexes heterocyclic thiosemicarbazide acyl pyrazolone DNA-interaction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100029
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spelling	oai:scielo:S0717-970720130001000292014-09-09SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONESSATHIYARAJ,SUBBAIYANJAYABALAKRISHNAN,CHINNASAMY Ruthenium(II) complexes heterocyclic thiosemicarbazide acyl pyrazolone DNA-interaction A new Schiff base ligands (H2L¹-H2L³) was synthesized by the condensation reaction of 4-acyl pyrazolones and 2-benzothiazolyl thiosemicarbazide. The ruthenium(II) Schiff base complexes were prepared by the interaction of the ligands with [RuHCl(CO)(EPh3)2(B)] (E=P/As; B=PPh3/AsPh3/py). They were characterized by elemental analysis, IR, UV-vis, ¹H, 13C, and 31P NMR spectral data. The interaction of the complexes with CT-DNA has been investigated by electronic absorption spectroscopy technique and the binding mode of the complexes with CT-DNA has been explored. Furthermore, the DNA cleavage activities of the complexes were performed by agarose gel electrophoresis on CT-DNA.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.1 20132013-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100029en10.4067/S0717-97072013000100029
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Ruthenium(II) complexes heterocyclic thiosemicarbazide acyl pyrazolone DNA-interaction
spellingShingle	Ruthenium(II) complexes heterocyclic thiosemicarbazide acyl pyrazolone DNA-interaction SATHIYARAJ,SUBBAIYAN JAYABALAKRISHNAN,CHINNASAMY SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES
description	A new Schiff base ligands (H2L¹-H2L³) was synthesized by the condensation reaction of 4-acyl pyrazolones and 2-benzothiazolyl thiosemicarbazide. The ruthenium(II) Schiff base complexes were prepared by the interaction of the ligands with [RuHCl(CO)(EPh3)2(B)] (E=P/As; B=PPh3/AsPh3/py). They were characterized by elemental analysis, IR, UV-vis, ¹H, 13C, and 31P NMR spectral data. The interaction of the complexes with CT-DNA has been investigated by electronic absorption spectroscopy technique and the binding mode of the complexes with CT-DNA has been explored. Furthermore, the DNA cleavage activities of the complexes were performed by agarose gel electrophoresis on CT-DNA.
author	SATHIYARAJ,SUBBAIYAN JAYABALAKRISHNAN,CHINNASAMY
author_facet	SATHIYARAJ,SUBBAIYAN JAYABALAKRISHNAN,CHINNASAMY
author_sort	SATHIYARAJ,SUBBAIYAN
title	SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES
title_short	SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES
title_full	SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES
title_fullStr	SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES
title_full_unstemmed	SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES
title_sort	synthesis, characterization, dna binding and cleavage activity of ruthenium(ii) complexes with heterocyclic substituted thiosemicarbazones
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000100029
work_keys_str_mv	AT sathiyarajsubbaiyan synthesischaracterizationdnabindingandcleavageactivityofrutheniumiicomplexeswithheterocyclicsubstitutedthiosemicarbazones AT jayabalakrishnanchinnasamy synthesischaracterizationdnabindingandcleavageactivityofrutheniumiicomplexeswithheterocyclicsubstitutedthiosemicarbazones
_version_	1718445484036587520

SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES

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