DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS

DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS

The ability of the body to maintain the flow of blood following vascular injury is an important process for the survival. Normally the process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, is known as hemostasis. Anticoagulants are widely...

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Autores principales: CHOUDHARI,PRAFULLA B, BHATIA,MANISH S
Lenguaje:English
Publicado: Sociedad Chilena de Química 2013
Materias:
Anticoagulants
Factor VIIa Inhibition
Docking
QSAR
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200005
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spelling oai:scielo:S0717-970720130002000052014-09-09DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORSCHOUDHARI,PRAFULLA BBHATIA,MANISH S Anticoagulants Factor VIIa Inhibition Docking QSAR The ability of the body to maintain the flow of blood following vascular injury is an important process for the survival. Normally the process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, is known as hemostasis. Anticoagulants are widely utilized in the treatment of all type of thromboembolism. The present communication deals with the design and docking studies of a series of N-Phenyl-3-Pyridin-2-yl imino analogs and their screening anticoagulants and virtually confirming the mechanism of action as factor VIIa Inhibitors. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the basis of consistent IR, 1H NMR, Mass spectroscopy and elemental analysis. All the synthesized compounds were found to exhibit profound anti coagulant activity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.2 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200005en10.4067/S0717-97072013000200005
institution Scielo Chile
collection Scielo Chile
language English
topic Anticoagulants
Factor VIIa Inhibition
Docking
QSAR
spellingShingle Anticoagulants
Factor VIIa Inhibition
Docking
QSAR
CHOUDHARI,PRAFULLA B
BHATIA,MANISH S
DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS
description The ability of the body to maintain the flow of blood following vascular injury is an important process for the survival. Normally the process of blood clotting and then the subsequent dissolution of the clot, following repair of the injured tissue, is known as hemostasis. Anticoagulants are widely utilized in the treatment of all type of thromboembolism. The present communication deals with the design and docking studies of a series of N-Phenyl-3-Pyridin-2-yl imino analogs and their screening anticoagulants and virtually confirming the mechanism of action as factor VIIa Inhibitors. The compounds were synthesized in excellent yields (70-80%) and the structures were established on the basis of consistent IR, 1H NMR, Mass spectroscopy and elemental analysis. All the synthesized compounds were found to exhibit profound anti coagulant activity.
author CHOUDHARI,PRAFULLA B
BHATIA,MANISH S
author_facet CHOUDHARI,PRAFULLA B
BHATIA,MANISH S
author_sort CHOUDHARI,PRAFULLA B
title DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS
title_short DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS
title_full DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS
title_fullStr DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS
title_full_unstemmed DEVELOPMENT OF N-PHENYL-3-PYRIDIN-2-YL IMINO DERIVATIVES AS ANTICOAGULANTS POTENTIAL FACTOR VIIA INHIBITORS
title_sort development of n-phenyl-3-pyridin-2-yl imino derivatives as anticoagulants potential factor viia inhibitors
publisher Sociedad Chilena de Química
publishDate 2013
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000200005
work_keys_str_mv AT choudhariprafullab developmentofnphenyl3pyridin2yliminoderivativesasanticoagulantspotentialfactorviiainhibitors
AT bhatiamanishs developmentofnphenyl3pyridin2yliminoderivativesasanticoagulantspotentialfactorviiainhibitors
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